Document Detail

The effect of chloroquine upon the developing eye of the chick embryo.
MedLine Citation:
PMID:  7458318     Owner:  NLM     Status:  MEDLINE    
The effect of chloroquine on the eyes of 8 (8DE) and 15 (15DE) day old chick embryos has been studied. Microphthalmus was observed in 30% of the 8DE and 80% of the 15DE. The most conspicuous changes were seen in the retina. In the 8DE, chloroquine mostly prevented the development of photo-receptors with subsequent adhesions between the pigment epithelium and external granular layer, or caused a destruction of the pigment epithelium with subsequent chorio-retinal adhesions. In the 15DE, chloroquine caused destruction of the whole retina. The choroid showed a hyperproliferation of the melanocytes in the 8DE, and edema in the 15DE. The lens showed moderate vacuolisation in the 8DE and severe cataract formation in the 15DE.
L Barr-Nea; Y R Barishak
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives d'anatomie microscopique et de morphologie expérimentale     Volume:  69     ISSN:  0003-9594     ISO Abbreviation:  Arch Anat Microsc Morphol Exp     Publication Date:  1980  
Date Detail:
Created Date:  1981-03-17     Completed Date:  1981-03-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0406007     Medline TA:  Arch Anat Microsc Morphol Exp     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  29-34     Citation Subset:  IM    
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MeSH Terms
Chick Embryo
Chloroquine / pharmacology*
Eye / drug effects,  embryology*
Reg. No./Substance:

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