Document Detail

The effect of chlorhexidine and zinc/triclosan mouthrinses on the production of acids in dental plaque.
MedLine Citation:
PMID:  8402805     Owner:  NLM     Status:  MEDLINE    
Chlorhexidine, and zinc in combination with triclosan, are used as anti-plaque agents in the prevention of gingivitis. The multifunctional activity of these compounds against bacterial cells has been proposed to include interference with sugar transport and reduction of glycolysis. In this study the ability of the agents to reduce acid production in dental plaque in vivo has been investigated. Samples of smooth-surface plaque were collected from individuals who had been rinsing for several weeks with (a) chlorhexidine (0.12%, Peridex); a combination of zinc and triclosan in mouthwashes containing (b) high and (c) low concentrations of humectant; or (d) a control mouthwash. Analyses using isotachophoresis showed that resting plaques in the chlorhexidine and zinc/triclosan groups contained less acetate than the control group. Acids were also measured 15 min after a glucose rinse. Compared with the control, the amount of lactate was significantly decreased (45%) in the chlorhexidine group, while lactate reduction (20%) in the zinc/triclosan (high humectant) group was not statistically significant.
J S van der Hoeven; D Cummins; M J Schaeken; F J van der Ouderaa
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Caries research     Volume:  27     ISSN:  0008-6568     ISO Abbreviation:  Caries Res.     Publication Date:  1993  
Date Detail:
Created Date:  1993-11-10     Completed Date:  1993-11-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0103374     Medline TA:  Caries Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  298-302     Citation Subset:  D; IM    
Laboratory of Oral Microbiology, Research Program TRIKON, University of Nijmegen, The Netherlands.
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MeSH Terms
Acetates / metabolism
Analysis of Variance
Bacteria / drug effects,  metabolism
Chlorhexidine / pharmacology*
Citrates / pharmacology
Citric Acid
Dental Plaque / metabolism*,  microbiology
Glycolysis / drug effects
Hydrogen-Ion Concentration
Lactates / biosynthesis*
Lactic Acid
Mouthwashes / pharmacology*
Triclosan / pharmacology*
Zinc Compounds / pharmacology*
Reg. No./Substance:
0/Acetates; 0/Citrates; 0/Lactates; 0/Mouthwashes; 0/Zinc Compounds; 3380-34-5/Triclosan; 50-21-5/Lactic Acid; 55-56-1/Chlorhexidine; 77-92-9/Citric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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