Document Detail


The effect of chemotherapy in pregnant women on the teeth of offspring.
MedLine Citation:
PMID:  14733479     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
No standardized therapeutic interventions have been reported for patients diagnosed with breast cancer during pregnancy. A high risk for malformations in the fetus has been claimed when chemotherapy is administered during the first trimester of the pregnancy. Tooth formation of the primary teeth begins at 11 to 14 weeks of fetal life and is completed postnatally. Therefore, the teeth may be affected by insults during the second and third trimesters of pregnancy, thus acting as a sensitive parameter of possible placental transfer of chemotherapy. The cases presented describe the dental status of 2 young children whose mothers received chemotherapy for cancer during the third trimester of their pregnancies (adriamycin or adriamycin and cytoxan). Both women gave birth to healthy babies, born with full hair, normal blood counts, and birth weights (3.200 and 3.100 kgs). Dental examinations of both children (at ages 18 and 30 months) revealed sound teeth. It seems that adriamycin and cytoxan for cancer chemotherapy do not affect the primary teeth when administered in the third trimester of pregnancy.
Authors:
Benjamin Peretz; Tamar Peretz
Related Documents :
11759139 - Anesthetic implications of a partial molar pregnancy and associated complications.
9243199 - A review of trophoblastic diseases at the medical school of dicle university.
15863179 - A successfully treated case of primary tubal choriocarcinoma coexistent with viable int...
17556829 - Fetus-in-fetu: parasite or neoplasm? a study of two cases.
22155199 - Pregnancy issues in scleroderma.
20103799 - Clinical findings of multiple pregnancy with a complete hydatidiform mole and coexistin...
21606169 - Paroxysmal nocturnal hemoglobinuria and pregnancy before the eculizumab era: the french...
18222449 - Midcycle pericoital intravaginal bee honey and royal jelly for male factor infertility.
17468199 - Insights into the uterus.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric dentistry     Volume:  25     ISSN:  0164-1263     ISO Abbreviation:  Pediatr Dent     Publication Date:    2003 Nov-Dec
Date Detail:
Created Date:  2004-01-21     Completed Date:  2004-02-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7909102     Medline TA:  Pediatr Dent     Country:  United States    
Other Details:
Languages:  eng     Pagination:  601-4     Citation Subset:  D; IM    
Affiliation:
Department of Pediatric Dentistry, The Hebrew University Hadassah School of Dental Medicine, Jerusalem, Israel. benny@cc.huji.ac.il
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Antineoplastic Agents / toxicity*
Breast Neoplasms / drug therapy*
Carcinoma, Ductal, Breast / drug therapy*
Child, Preschool
Cyclophosphamide / toxicity*
Doxorubicin / toxicity*
Female
Humans
Infant
Infant, Newborn
Pregnancy
Pregnancy Complications, Neoplastic / drug therapy*
Pregnancy Trimester, Third
Tooth, Deciduous / drug effects*
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 23214-92-8/Doxorubicin; 50-18-0/Cyclophosphamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Early childhood caries lesions in preschool children in Kerala, India.
Next Document:  Domestic pigeons (Columba livia) discriminate between photographs of individual pigeons.