Document Detail


The effect of changing intraocular pressure on the corneal and scleral curvatures in the fresh porcine eye.
MedLine Citation:
PMID:  17151057     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To measure corneal and scleral radii of curvature in response to intraocular pressure (IOP). METHODS: Using digital photographic profile images of 16 fresh porcine eyes, the curvatures of the cornea and sclera were determined in response to five consecutive incremental 100 mul saline intravitreal injections. IOP was measured and ocular rigidity calculated. Elastic moduli of the cornea and sclera were estimated. RESULTS: Intraocular pressure and the radius of curvature of the sclera increased linearly with increasing volume. There was no statistical change in corneal curvature. The elasticity of the cornea and sclera was constant during the 15-50 mm Hg increase in IOP. The estimated range of the elastic moduli of the cornea and sclera were, respectively 0.07-0.29 MPa and 0.2 MPa to 0.5 MPa. The scleral rigidity ranged from 0.0017 to 0.0022. CONCLUSIONS: The elastic moduli of the cornea and sclera are independent of IOP. The modulus of elasticity of the sclera is higher than that of the cornea. Elevation of IOP changes the curvature of the sclera but not that of the cornea. Porcine scleral rigidity is similar to human scleral rigidity. Scleral curvature could be a novel method for measuring IOP.
Authors:
B K Pierscionek; M Asejczyk-Widlicka; R A Schachar
Related Documents :
419977 - Pilocarpine medication in open-angle glaucoma. a study using pilocarpine eyedrops and a...
1428557 - Pr vecps related to ciliary perfusion pressure in primary open angle glaucoma. a study ...
2902177 - Ly141865: a relatively selective da2 agonist with complex ocular activity.
15117567 - Efficacy of bimatoprost 0.03 percent in untreated glaucoma and ocular hypertension pati...
22088437 - Increased urinary protein excretion in the "normal" range is associated with increased ...
4021317 - Effects of intra-animal nephron heterogeneity on studies of glomerular dynamics.
Publication Detail:
Type:  Journal Article     Date:  2006-12-06
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  91     ISSN:  0007-1161     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-18     Completed Date:  2007-07-23     Revised Date:  2010-09-14    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  801-3     Citation Subset:  IM    
Affiliation:
Department of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland BT52 1SA, UK. b.pierscionek@ulster.ac.uk
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cornea / anatomy & histology,  physiology*
Elasticity
Intraocular Pressure / physiology*
Models, Biological
Photography
Sclera / anatomy & histology,  physiology*
Stress, Mechanical
Swine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Soluble vascular endothelial growth factor receptor-1 contributes to the corneal antiangiogenic barr...
Next Document:  Use of optical coherence tomography, fluorescein angiography and indocyanine green angiography in a ...