Document Detail


The effect of changes in stimulus level on electrically evoked cortical auditory potentials.
MedLine Citation:
PMID:  19322089     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The purpose of this study was to determine whether the electrically evoked acoustic change complex (EACC) could be used to assess sensitivity to changes in stimulus level in cochlear implant (CI) recipients and to investigate the relationship between EACC amplitude and rate of growth of the N1-P2 onset response with increases in stimulus level.
DESIGN: Twelve postlingually deafened adults using Nucleus CI24 CIs participated in this study. Nucleus Implant Communicator (NIC) routines were used to bypass the speech processor and to control the stimulation of the implant directly. The stimulus consisted of an 800 msec burst of a 1000 pps biphasic pulse train. A change in the stimulus level was introduced 400 msec after stimulus onset. Band-pass filtering (1 to 100 Hz) was used to minimize stimulus artifact. Four to six recordings of 50 sweeps were obtained for each condition, and averaged responses were analyzed in the time domain using standard peak picking procedures.
RESULTS: Cortical auditory change potentials were recorded from CI users in response to both increases and decreases in stimulation level. The amplitude of the EACC was found to be dependent on the magnitude of the stimulus change. Increases in stimulus level elicited more robust EACC responses than decreases in stimulus level. Also, EACC amplitudes were significantly correlated with the slope of the growth of the onset response.
CONCLUSIONS: This work describes the effect of change in stimulus level on electrically evoked auditory change potentials in CI users. The amplitude of the EACC was found to be related both to the magnitude of the stimulus change introduced and to the rate of growth of the N1-P2 onset response. To the extent that the EACC reflects processing of stimulus change, it could potentially be a valuable tool for assessing neural processing of the kinds of stimulation patterns produced by a CI. Further studies are needed, however, to determine the relationships between the EACC and psychophysical measures of intensity discrimination in CI recipients.
Authors:
Jae-Ryong Kim; Carolyn J Brown; Paul J Abbas; Christine P Etler; Sara O'Brien
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Ear and hearing     Volume:  30     ISSN:  1538-4667     ISO Abbreviation:  Ear Hear     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-09-24     Completed Date:  2009-10-29     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  8005585     Medline TA:  Ear Hear     Country:  United States    
Other Details:
Languages:  eng     Pagination:  320-9     Citation Subset:  IM    
Affiliation:
Department of Otolaryngology - Head and Neck Surgery, University of Iowa, Iowa City, Iowa 52242, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Artifacts
Auditory Cortex / physiology*
Auditory Perception / physiology
Cochlear Implants*
Deafness / physiopathology*,  therapy*
Electric Stimulation*
Evoked Potentials, Auditory / physiology*
Female
Humans
Male
Middle Aged
Psychoacoustics
Sensitivity and Specificity
Grant Support
ID/Acronym/Agency:
DC00242/DC/NIDCD NIH HHS; P50 DC000242-240002/DC/NIDCD NIH HHS; RR00059/RR/NCRR NIH HHS
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