| The effect of cephalothin prophylaxis on postoperative ventriculoperitoneal shunt infections. | |
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MedLine Citation:
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PMID: 3552176 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Postoperative infection is an important complication after insertion of a ventriculoperitoneal (VP) shunt in children with hydrocephalus. A randomized double-blind placebo-controlled study was performed to determine the efficacy of cephalothin in preventing postoperative shunt infection. Sixty-three children who presented for elective VP shunt insertion between January 1982 and December 1985 and who did not have a history of shunt infections were randomly assigned to receive four doses of prophylactic cephalothin, 25 mg/kg (32 patients), or of a multivitamin placebo (31 patients). Postoperative infection developed in 6% of the treatment group, compared with 10% of the placebo group, a difference that was not statistically significant, although a clinical significance may have been masked by the small sample size. A large multicentre trial is needed to determine the efficacy of antibiotic prophylaxis in reducing the incidence of postoperative VP shunt infections. |
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Authors:
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M J Rieder; T C Frewen; R F Del Maestro; A Coyle; S Lovell |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne Volume: 136 ISSN: 0820-3946 ISO Abbreviation: CMAJ Publication Date: 1987 May |
Date Detail:
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Created Date: 1987-05-26 Completed Date: 1987-05-26 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 9711805 Medline TA: CMAJ Country: CANADA |
Other Details:
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Languages: eng Pagination: 935-8 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacterial Infections
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prevention & control* Cephalothin / administration & dosage, therapeutic use* Cerebrospinal Fluid Shunts* Child Child, Preschool Clinical Trials as Topic Double-Blind Method Female Humans Hydrocephalus / surgery Infant Infant, Newborn Male Peritoneal Cavity Premedication* Random Allocation Surgical Wound Infection / prevention & control* |
| Chemical | |
Reg. No./Substance:
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153-61-7/Cephalothin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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