Document Detail

The effect of catecholamine precursor L-dopa on sleep bruxism: a controlled clinical trial.
MedLine Citation:
PMID:  8990057     Owner:  NLM     Status:  MEDLINE    
The putative role of the dopaminergic system in sleep bruxism (SB) was studied in a double-blind clinical trial by using low doses of short-term L-dopa in combination with benserazide. We recorded 10 patients with SB in our sleep laboratory for 3 consecutive nights. The first night was for habituation to the laboratory environment. During the second and the third nights, the patients received two doses of either L-dopa or a placebo in a crossover fashion: the first dose 1 h before bedtime and the second, 4 h after the first one. The order of administration was reversed in half the patients. The efficacy of L-dopa was analyzed by using multilevel models. L-Dopa resulted in a significant decrease in the average number of bruxism episodes per hour of sleep, as well as in a significant reduction in the average value of the root-mean-square (RMS) electromyography (EMG) level per bruxism burst. This indicates that L-dopa exerts an attenuating effect on SB. In addition, L-dopa caused a reduction in the variance in RMS values, which suggests that L-dopa normalizes the EMG activity patterns associated with SB.
F Lobbezoo; G J Lavigne; R Tanguay; J Y Montplaisir
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  12     ISSN:  0885-3185     ISO Abbreviation:  Mov. Disord.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-04-02     Completed Date:  1997-04-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  73-8     Citation Subset:  IM    
Département de Physiologie, Faculté de Médecine, Université de Montréal, Québec, Canada.
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MeSH Terms
Benserazide / administration & dosage
Bruxism / drug therapy*
Cross-Over Studies
Dopamine Agents / administration & dosage*
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Drug Combinations
Electromyography / drug effects
Levodopa / administration & dosage*
Sleep Disorders / drug therapy*
Reg. No./Substance:
0/Dopamine Agents; 0/Drug Combinations; 0/Levodopa; 322-35-0/Benserazide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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