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The effect of β-carotene on lumbar osteophyte formation.
MedLine Citation:
PMID:  21673632     Owner:  NLM     Status:  Publisher    
Study Design. Cross-sectional cohort study of elderly people.Objectives. The relationships of osteophyte formation on plain lumbar radiographs with serum levels of antioxidants (carotenoids, vitamin A, vitamin E) and other factors were investigated to examine if antioxidants are involved in lumbar spine degeneration.Summary of Background Data. Antioxidants have inhibitory effects on onset of many diseases. However, the association of lumbar osteophyte formation with antioxidant levels in the general population has not been investigated.Methods. The subjects were 286 persons (male, 103; female, 183; mean age, 68 years old) who underwent resident health screening. Osteophyte formation on lumbar lateral radiographs (Nathan classification), lumbar lordosis angles, sacral inclination angles, serum levels of antioxidants, triglyceride levels, body mass index, osteoporosis, back muscle strength, history of alcohol intake, and smoking history were studied in these subjects.Results. Lumbar osteophyte formation was detected in 48 subjects (17%). Osteophyte formation was significantly more common in elderly persons, males, and subjects with a history of alcohol intake; and had a significant correlation with sacral inclination angle. The levels of α-tocopherol, β-tocopherol, zeaxanthin/lutein, cryptoxanthin, lycopene, α-carotene, and β-carotene were significantly lower in subjects with osteophytes. Logistic regression analysis adjusted for all factors showed that a high age (odds ratio (OR) 1.1, 95% confidence interval (95%CI) 1.02-1.16, p = 0.02) and a low β-carotene level (OR 6.7, 95%CI 1.39-32.6, p = 0.02) were risk factors for osteophyte formation.Conclusions. The serum levels of carotenoids and vitamin E were significantly lower in subjects with lumbar osteophyte formation, and a low β-carotene level was the strongest risk factor for lumbar osteophytes. This is the first evidence of an association between carotenoids and lumbar osteophyte formation. This finding suggests that appropriate dietary intake of antioxidants is important for inhibition of lumbar spine degeneration in a rapidly aging society.
Shiro Imagama; Yukiharu Hasegawa; Taisuke Seki; Yukihiro Matsuyama; Yoshihito Sakai; Zenya Ito; Naoki Ishiguro; Yoshinori Ito; Nobuyuki Hamajima; Koji Suzuki
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-13
Journal Detail:
Title:  Spine     Volume:  -     ISSN:  1528-1159     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7610646     Medline TA:  Spine (Phila Pa 1976)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, 65, Tsurumai, Showa-ku, Nagoya, Aichi, 466-8550, Japan. Department of Orthopaedic Surgery, Hamamatsu University School of Medicine, 1-20-1, Handayama, Higashi-ku, Hamamatsu, Shizuoka, 431-3192, Japan Department of Restorative Medicine, National Center for Geriatrics and Gerontology, Gengo 36-3, Morioka-cho, Obu, Aichi, 474-8511, Japan. Department of Orthopaedic Surgery, Toyohashi Municipal Hospital, 50, Hachikennishi, Aotake-cho, Toyohashi, Aichi, 441-8570, Japan. Department of Preventive Medicine/Biostatistcs and Medical Decision Making, Nagoya University Graduate School of Medicine, 65, Tsurumai, Showa-ku, Nagoya, Aichi, 466-8550, Japan Department of Public Health, Fujita Health University of Health Sciences, Toyoake, Aichi, Japan.
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