| The effect of cardiac arrest on the blood-testis barrier to albumin, tumor necrosis factor-alpha, pituitary adenylate cyclase activating polypeptide, sucrose, and verapamil in the mouse. | |
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MedLine Citation:
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PMID: 11229799 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Impotence commonly occurs after events such as acute myocardial infarction, coronary bypass, head trauma, and cerebral bleeding, including subarachnoid hemorrhage. We hypothesize that the hypoxia accompanying these events could damage the blood-testis barrier (BTB) and so cause testicular dysfunction, a possible cause of impotence. We examined the effect of cardiac arrest in mice on testis weight and various aspects of BTB function. Testis weight was decreased by about 24% 12 hours after cardiac arrest but had recovered fully by day 7. The testis/serum ratio for albumin was increased 12 hours after arrest, showing a disruption in the vascular BTB with recovery by 24 hours. The testis/serum ratio for sucrose was not consistently elevated, showing that the Sertoli cell BTB remained intact. The testis/serum ratio for verapamil was increased on day 3 of cardiac arrest, suggesting impaired function of the BTB's p-glycoprotein efflux transporter. Transporters for pituitary adenylate cyclase activating polypeptide and tumor necrosis factor-alpha were not affected by cardiac arrest. These results show that cardiac arrest affects testis weight and some aspects of BTB function. Such changes might have long-term effects on testicular function. |
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Authors:
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H Mizushima; Y Nakamura; H Matsumoto; K Dohi; K Matsumoto; S Shioda; W A Banks |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of andrology Volume: 22 ISSN: 0196-3635 ISO Abbreviation: J. Androl. Publication Date: 2001 Mar-Apr |
Date Detail:
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Created Date: 2001-03-02 Completed Date: 2001-05-17 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8106453 Medline TA: J Androl Country: United States |
Other Details:
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Languages: eng Pagination: 255-60 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Showa University School of Medicine, Tokyo, Japan. mizu@med.showa-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Albumins
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metabolism* Animals Heart Arrest / metabolism* Male Mice Mice, Inbred ICR Neuropeptides / blood, metabolism* Pituitary Adenylate Cyclase-Activating Polypeptide Sucrose / blood, metabolism* Testis / physiopathology* Tumor Necrosis Factor-alpha / metabolism* Verapamil / blood, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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R01 MH54979/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adcyap1 protein, mouse; 0/Albumins; 0/Neuropeptides; 0/Pituitary Adenylate Cyclase-Activating Polypeptide; 0/Tumor Necrosis Factor-alpha; 52-53-9/Verapamil; 57-50-1/Sucrose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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