Document Detail


The effect of carcinoma of the cervix on the L-lactate-nicotinamide-adenine dinucleotide oxidoreductase activity in vaginal aspirates.
MedLine Citation:
PMID:  7459289     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lactate dehydrogenase (L-lactate-NAD+ oxidoreductase; EC 1.1.1.27) has been assayed in saline extracts of vaginal aspirates obtained from patients with carcinoma in situ and from patients with clinically detectable invasive carcinoma of the cervix. Taking premenopausal and postmenopausal patients separately, significant differences were found between the aspirate lactate dehydrogenase activities obtained from patients with carcinoma in situ and the activities obtained from patients with invasive carcinoma; generally higher activities were obtained from the latter. With the exception of postmenopausal patients with carcinoma in situ, aspirate enzyme activities obtained from both groups of patients were significantly different from those obtained from normal women. Significantly higher lactate dehydrogenase activity was found in aspirates from patients for whom histology showed the presence of an adenocarcinoma or certain highly malignant cell types. Treatment by radium insertion usually resulted in a fall total lactate dehydrogenase activity. Significant differences between groups were found for the proportions of single lactate dehydrogenase isoenzymes in a few instances but no significant difference in overall isoenzyme distribution was found.
Authors:
A V Emes; A L Latner; D Guthrie; P R Philips; S A Way
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  88     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1981 Jan 
Date Detail:
Created Date:  1981-04-13     Completed Date:  1981-04-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  36-41     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Body Fluids / enzymology
Carcinoma in Situ / enzymology
Clinical Enzyme Tests
Female
Humans
Isoenzymes / metabolism
L-Lactate Dehydrogenase / metabolism*
Menopause
Uterine Cervical Neoplasms / diagnosis,  enzymology*,  therapy
Vagina / enzymology*
Chemical
Reg. No./Substance:
0/Isoenzymes; EC 1.1.1.27/L-Lactate Dehydrogenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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