| The effect of carcinogens on the nuclear size of HeLa cells. | |
| | |
MedLine Citation:
|
PMID: 653739 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The size of HeLa S-3 cell nuclei was measured after 1--3 days in culture. After exposure to carcinogens, nuclear size increased and the frequency distribution pattern of nuclear size changed. The optimal conditions for these changes were the use of concentrations of chemicals which had a low order of cytotoxicity and the measurement of nuclear size 48 h after pulse treatment of the cells for 30--60 min. These effects were not seen with non-carcinogens. The results obtained suggest that changes in nuclear size may be an index of chemical carcinogenicity. |
| | |
Authors:
|
C E Agrelo |
Related Documents
:
|
1820339 - Mutagenicity and effects of ochratoxin a on the frequency of sister chromatid exchange ... 7394519 - Carcinogenic activity of particulate nickel compounds is proportional to their cellular... 3170449 - Cytokinetics and sce baselines in rat and human lymphocytes during successive divisions... 3793119 - Interaction between some common genotoxic agents. 21167879 - Evaluation of the bd mgit tbc identification test (tbc id), a rapid chromatographic imm... 8070649 - Poisson-like fluctuation patterns of revertants of leucine auxotrophy (leu-500) in salm... 8603859 - Isolation and characterization of porcine müller cells. myofibroblastic dedifferentiat... 9159439 - Assessment of the need for follicle stimulating hormone in early preantral mouse follic... 15910179 - Low-level laser irradiation promotes proliferation and differentiation of human osteobl... |
Publication Detail:
|
Type: In Vitro; Journal Article |
Journal Detail:
|
Title: Toxicology Volume: 9 ISSN: 0300-483X ISO Abbreviation: Toxicology Publication Date: 1978 Feb |
Date Detail:
|
Created Date: 1978-07-15 Completed Date: 1978-07-15 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0361055 Medline TA: Toxicology Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 21-7 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Carcinogens / pharmacology* Cell Nucleus / drug effects*, ultrastructure Hela Cells / ultrastructure Humans Liver / ultrastructure Male Mitomycins / pharmacology Mitosis / drug effects Rats Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Carcinogens; 0/Mitomycins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Heme synthesis in the lead-intoxicated mouse embryo.
Next Document: Short-term toxicity of allyl alcohol in rats.