Document Detail

The effect of carbonic anhydrase inhibition on breathing movements and electrocortical activity in fetal sheep.
MedLine Citation:
PMID:  3933069     Owner:  NLM     Status:  MEDLINE    
Fetal breathing movements (FBM) indicated by repetitive negative intrathoracic pressures and biparietal electrocorticograms (ECoG) were recorded from 8 fetal sheep for 3 h before (control) and 3 h after the administration of a carbonic anhydrase inhibitor, acetazolamide. FBM and the low voltage (LV) ECoG state occurred 36 +/- 5% (SEM) and 60 +/- 3% of the control period, respectively. Virtually no FBM occurred during high voltage (HV) ECoG while in 57 +/- 6% of the LV state the fetuses were making FBM. The peak magnitude of the negative intrathoracic (tracheal) pressure deflections was 4 +/- 1 Torr. Following acetazolamide the incidence of FBM rose to 53 +/- 4% (P less than 0.01) but there was no significant change in the incidence of the LV state (58 +/- 3%). Most of the increase in the incidence of FBM remained confined to periods of LV ECoG activity so that an increased proportion of this state (88 +/- 2%, P less than 0.001) was occupied with respiratory efforts. The amplitude of the FBM also increased to 8 +/- 1 Torr (P less than 0.05). The increased incidence and depth of FBM is most likely due to an elevated hydrogen ion concentration and differs from a fetal respiratory acidosis induced by increasing the inspired CO2 fraction to the ewe in that the respiratory stimulation induced by acetazolamide is not associated with an increased incidence of the permissive LV ECoG state.
A R Hohimer; J M Bissonnette; C M Machida; B Horowitz
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Respiration physiology     Volume:  61     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1985 Sep 
Date Detail:
Created Date:  1985-12-03     Completed Date:  1985-12-03     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  327-34     Citation Subset:  IM    
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MeSH Terms
Acetazolamide / pharmacology*
Carbon Dioxide / blood
Carbonic Anhydrase Inhibitors / pharmacology
Cerebral Cortex / drug effects,  physiology*
Chemoreceptor Cells / physiology
Fetal Blood / metabolism
Fetus / physiology*
Hydrogen-Ion Concentration
Oxygen / blood
Respiration / drug effects*
Sleep / physiology
Trachea / physiology
Grant Support
Reg. No./Substance:
0/Carbonic Anhydrase Inhibitors; 124-38-9/Carbon Dioxide; 59-66-5/Acetazolamide; 7782-44-7/Oxygen

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