Document Detail


The effect of carbonic anhydrase inhibition on bicarbonate reabsorption.
MedLine Citation:
PMID:  4767     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Renal reabsorption of bicarbonate was studied in Merino ewes during carbonic anhydrase inhibition. Bicarbonate reabsorption was directly proportional to plasma bicarbonate concentration. No tubular maximum for bicarbonate was demonstrated. Elevation of arterial PCO2 or depression of arterial pH caused slight increases in bicarbonate reabsorption. The data suggest that bicarbonate is reabsorbed by 2 distinct processes. The quantitatively more significant process may involve ionic reabsorption of bicarbonate secondary to Na+ reabsorption and a relatively minor part of bicarbonate reabsorption may be secondary to H+ secretion.
Authors:
B D Slaughter; H S Osiecki; R B Cross
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  362     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  1976 Apr 
Date Detail:
Created Date:  1976-07-06     Completed Date:  1976-07-06     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  203-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetazolamide / pharmacology*
Animals
Bicarbonates / metabolism*
Biological Transport
Blood
Carbon Dioxide / blood
Carbonic Anhydrase Inhibitors
Carbonic Anhydrases / metabolism*
Female
Glomerular Filtration Rate
Hydrogen-Ion Concentration
Kidney Tubules, Proximal / enzymology,  metabolism*
Partial Pressure
Sheep
Sodium / metabolism
Chemical
Reg. No./Substance:
0/Bicarbonates; 0/Carbonic Anhydrase Inhibitors; 124-38-9/Carbon Dioxide; 59-66-5/Acetazolamide; 7440-23-5/Sodium; EC 4.2.1.1/Carbonic Anhydrases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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