Document Detail


The effect of calendula officinalis in therapy of acetic Acid induced ulcerative colitis in dog as an animal model.
MedLine Citation:
PMID:  22737434     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: In patients with ulcerative colitis (UC), the repeated cycle of injury and repair of intestinal mucosa has been reported to increase the risk of colon cancer. So, a safe and efficient therapy is required for the treatment and prophylaxis for the disease.This study aims to investigate the efficacy of Calendula officinalis extract in treatment of experimentally induced ulcerative colitis in dog animal model.
METHODS: During fall 2010, 10 out-bred female German dogs (1-2 years old; weighs of 20-25 kg) were enrolled. Ulcerative colitis was induced with 6% acetic acid as enema and method of treatment was retrograde (via enema) too by C. officinalis.
RESULTS: Loose stools, diarrhea, gross bleeding and loss of body weight happened after administration of acetic acid and crypt damage, loss of epithelium, infiltration of inflammatory cells and depletion of goblet cells were noticed histologically. C. officinalis could successfully resolve the damages of UC.
CONCLUSION: Treatment with C. officinalis can broaden the current therapy options for UC.
Authors:
D Mehrabani; M Ziaei; S V Hosseini; L Ghahramani; A M Bananzadeh; M J Ashraf; A Amini; M Amini; N Tanideh
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Publication Detail:
Type:  Journal Article     Date:  2011-12-01
Journal Detail:
Title:  Iranian Red Crescent medical journal     Volume:  13     ISSN:  2074-1812     ISO Abbreviation:  Iran Red Crescent Med J     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2012-06-27     Completed Date:  2012-08-23     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101319850     Medline TA:  Iran Red Crescent Med J     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  884-90     Citation Subset:  -    
Affiliation:
Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
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