Document Detail

The effect of calcium phosphate implant coating on osteoconduction.
MedLine Citation:
PMID:  11740476     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to determine whether a calcium phosphate (CaP) coating would have a significant impact on osteoconduction.
STUDY DESIGN: In this investigation, porous-surfaced titanium alloy (Ti-6Al-4V) implants were prepared with or without the addition of a thin surface layer of CaP applied by means of sol-gel coating and implanted into the tibiae of 16 rabbits. Implant sites were allowed to heal for 2 weeks, after which specimens were retrieved for morphometric assessment by using backscatter scanning electron microscopy and the Bioquant Image Analyzer.
RESULTS: The absolute contact length was significantly (P <.01) higher for CaP-coated implants (1.18 mm) than for the noncoated implants (0.74 mm), as were the contact length fraction (40.4% vs 27.0%; P <.01) and the straight-line bone growth (1.19 mm vs 1.04 mm; P <.01).
CONCLUSION: On the basis of the findings in this study, the addition of a thin layer of CaP to the implant promotes accelerated bone healing around porous-surfaced implants-even after only 2 weeks of initial healing.
C Yang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics     Volume:  92     ISSN:  1079-2104     ISO Abbreviation:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-12-12     Completed Date:  2002-03-04     Revised Date:  2014-07-28    
Medline Journal Info:
Nlm Unique ID:  9508562     Medline TA:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  606-9     Citation Subset:  D; IM    
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MeSH Terms
Analysis of Variance
Calcium Phosphates / pharmacology*
Coated Materials, Biocompatible / pharmacology*
Implants, Experimental*
Models, Animal
Osteogenesis / drug effects*
Statistics, Nonparametric
Tibia / surgery
Reg. No./Substance:
0/Calcium Phosphates; 0/Coated Materials, Biocompatible; 0/alpha-tricalcium phosphate; 0/tetracalcium phosphate; 12743-70-3/titanium alloy (TiAl6V4); 701EKV9RMN/calcium phosphate, monobasic, anhydrous; 97Z1WI3NDX/calcium phosphate; D1JT611TNE/Titanium; L11K75P92J/calcium phosphate, dibasic, anhydrous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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