Document Detail


The effect of calcium antagonists on atrial natriuretic peptide (ANP) release from the rat heart during rapid cardiac pacing.
MedLine Citation:
PMID:  2528639     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The diuresis associated with rapid atrial rhythms is a well recognized clinical entity (Wood, 1963). Atrial natriuretic peptide (ANP) levels are elevated during rapid atrial rhythms (Hirata et al., 1987), including during rapid atrial pacing (Rankin et al., 1986; Schiebinger and Linden 1986; Walsh et al., 1987), and may contribute to the associated diuresis. Calcium channel antagonists are often used to treat atrial tachycardias but the effect this may have on ANP secretion and subsequent compensatory responses, such as a diuresis, is unknown. Reported here are experiments demonstrating that the increase in ANP secretion that accompanies rapid atrial pacing of the isolated perfused rat heart is abolished by calcium channel antagonists. This effect is not limited to a single class of calcium channel antagonists and could be demonstrated with Verapamil and Nifedipine. Although extrapolation to the in vivo situation should always be done with care, the results reported here contribute towards clarifying the effect of the calcium channel antagonists on the ANP response to rapid heart rates.
Authors:
A F Doubell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of molecular and cellular cardiology     Volume:  21     ISSN:  0022-2828     ISO Abbreviation:  J. Mol. Cell. Cardiol.     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-10-25     Completed Date:  1989-10-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0262322     Medline TA:  J Mol Cell Cardiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  437-40     Citation Subset:  IM    
Affiliation:
MRC Centre for Molecular and Cellular Biology, University of Stellenbosch Medical School, Cape Town, South Africa.
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MeSH Terms
Descriptor/Qualifier:
Animals
Atrial Natriuretic Factor / analysis,  secretion*
Calcium Channel Blockers / pharmacology*
Cardiac Pacing, Artificial
Heart / drug effects,  physiology*
Heart Rate*
Kinetics
Male
Nifedipine / pharmacology
Perfusion
Rats
Rats, Inbred Strains
Verapamil / pharmacology
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers; 21829-25-4/Nifedipine; 52-53-9/Verapamil; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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