| The effect of calcitonin gene-related peptide on pancreatic blood flow and secretion in conscious dogs. | |
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MedLine Citation:
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PMID: 11257309 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of human alpha-calcitonin gene-related peptide (alpha-CGRP) and beta-CGRP on pancreatic arterial (PA), superior mesenteric (SMA) and left gastric arterial (LGA) blood flows were studied by ultrasound transit-time blood flow meters in five conscious dogs. Intravenous injections of alpha-CGRP and beta-CGRP (5-200 pmol/kg) induced a dose-related increase in PA flow and a dose-related decrease in its resistance. At lower doses, alpha-CGRP was more potent than beta-CGRP, but their maximal responses were similar. The blood flow responses to alpha-CGRP (200 pmol/kg) were 153% of the basal flow in LGA, 313% in PA, and 534% in SMA, while those to VIP (100 pmol/kg) were 467% in LGA, 953% in PA and 163% in SMA. Somatostatin reduced blood flow in all arteries. alpha-CGRP, but not beta-CGRP, at higher doses induced gastric contractions and pancreatic protein-rich secretion, which were blocked by atropine. These results suggest that CGRP in perivascular nerves in the pancreas may regulate pancreatic blood flow in dogs but its physiological function remains to be studied. |
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Authors:
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C Jin; S Naruse; M Kitagawa; H Ishiguro; M Nakajima; N Mizuno; S B Ko; T Hayakawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Regulatory peptides Volume: 99 ISSN: 0167-0115 ISO Abbreviation: Regul. Pept. Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-03-21 Completed Date: 2001-07-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8100479 Medline TA: Regul Pept Country: Netherlands |
Other Details:
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Languages: eng Pagination: 9-15 Citation Subset: IM |
Affiliation:
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Internal Medicine II, Nagoya University School of Medicine, 65 Tsurumai-cho, Nagoya 466-8550, Showa, Japan. snaruse@med.nagoya-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Calcitonin Gene-Related Peptide / pharmacology* Dogs Female Heart Rate / drug effects Humans Male Mesenteric Artery, Superior / drug effects, physiology Pancreas / blood supply, drug effects*, secretion Regional Blood Flow / drug effects Somatostatin / pharmacology Vasoactive Intestinal Peptide / pharmacology |
| Chemical | |
Reg. No./Substance:
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37221-79-7/Vasoactive Intestinal Peptide; 51110-01-1/Somatostatin; 83652-28-2/Calcitonin Gene-Related Peptide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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