Document Detail

The effect of caffeine on pregnancy outcome variables.
MedLine Citation:
PMID:  8918140     Owner:  NLM     Status:  MEDLINE    
The American public consumes a wide array of caffeinated products as coffee, tea, chocolate, cola beverages, and caffeine-containing medication. Therefore, it seems of value to inform both the scientific community and the consumer about the potential effects of excessive caffeine consumption, particularly by pregnant women. The results of this literature review suggest that heavy caffeine use (> or = 300 mg per day) during pregnancy is associated with small reductions in infant birth weight that may be especially detrimental to premature or low-birth-weight infants. Some researchers also document an increased risk of spontaneous abortion associated with caffeine consumption prior to and during pregnancy. However, overwhelming evidence indicates that caffeine is not a human teratogen, and that caffeine appears to have no effect on preterm labor and delivery. More research is needed before unambiguous statements about the effects of caffeine on pregnancy outcome variables can be made.
T S Hinds; W L West; E M Knight; B F Harland
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nutrition reviews     Volume:  54     ISSN:  0029-6643     ISO Abbreviation:  Nutr. Rev.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1997-01-06     Completed Date:  1997-01-06     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0376405     Medline TA:  Nutr Rev     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  203-7     Citation Subset:  IM    
Center for Drug Abuse Research, Howard University, Washington, DC, USA.
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MeSH Terms
Abnormalities, Drug-Induced / epidemiology
Abortion, Spontaneous / chemically induced,  epidemiology
Caffeine / adverse effects,  metabolism,  pharmacology*
Dose-Response Relationship, Drug
Infant, Low Birth Weight / physiology
Infant, Newborn
Pregnancy / drug effects*,  metabolism,  physiology
Pregnancy Outcome*
Risk Factors
Xanthines / metabolism
Reg. No./Substance:
0/Xanthines; 28109-92-4/methylxanthine; 58-08-2/Caffeine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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