| The effect of caffeine and alcohol consumption on liver fibrosis - a study of 1045 Asian hepatitis B patients using transient elastography. | |
| | |
MedLine Citation:
|
PMID: 21733095 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Background: Role of caffeine consumption in chronic hepatitis B virus (HBV)-infected patients and the interaction with alcohol consumption is unclear. Aim: This study aimed to investigate the relationship between caffeine and alcohol consumption and liver stiffness in chronic HBV-infected patients. Methods: Chronic HBV-infected patients who underwent transient elastography examination in 2006-2008 were studied. Advanced fibrosis was defined as liver stiffness >9 kPa for patients with normal alanine aminotransferase (ALT) or >12 kPa for those with elevated ALT according to previous validation study. Caffeine and alcohol consumption was recorded using a standardized questionnaire. Excessive alcohol intake was defined as 30 g/day in men and 20 g/day in women. Results: The liver stiffness of 1045 patients who completed the questionnaire was 8.3 ± 6.2 kPa. Two hundred and sixteen (20.7%) patients had advanced fibrosis. Ninety-five (19.0%) patients who drank ≥1 cup of coffee had advanced fibrosis, compared with 121 (22.2%) patients who drank <1 cup (P=0.21). The amount of caffeine intake had positive correlation with the amount of alcohol intake (r(s) =0.167, P<0.001). Although 231 (22.1%) patients reported alcohol consumption, only 11 (1%) had excessive alcohol intake. The prevalence of advanced fibrosis among patients with mild to moderate alcohol intake (26, 18.8%) was comparable to that among non-drinkers (190, 21.0%) (P=0.57). Conclusion: Caffeine intake does not affect liver stiffness in chronic HBV-infected patients. Patients who drink coffee regularly tend to drink alcohol. Most chronic HBV-infected patients do not have excessive alcohol consumption. The prevalence of advanced fibrosis among mild to moderate alcohol drinkers was low in this population. |
| | |
Authors:
|
Arlinking Ong; Vincent Wai-Sun Wong; Grace Lai-Hung Wong; Henry Lik-Yuen Chan |
Related Documents
:
|
21254375 - Multiple target molecular monitoring of bone marrow and peripheral blood samples from p... 12201005 - Treating vertigo with vestibular rehabilitation: results in 155 patients. 6830925 - Abnormal visual--vestibular interactions in psychosis. 19408505 - Hearing loss and vestibular function correlation in menière's disease patients. 21951115 - Diagnostic accuracy and therapeutic impact of endoscopic ultrasonography in patients wi... 7074335 - Biliary and pancreatoduodenal diversion by means of an isolated jejunal loop. |
Publication Detail:
|
Type: Journal Article Date: 2011-05-31 |
Journal Detail:
|
Title: Liver international : official journal of the International Association for the Study of the Liver Volume: 31 ISSN: 1478-3231 ISO Abbreviation: Liver Int. Publication Date: 2011 Aug |
Date Detail:
|
Created Date: 2011-07-07 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101160857 Medline TA: Liver Int Country: England |
Other Details:
|
Languages: eng Pagination: 1047-53 Citation Subset: IM |
Copyright Information:
|
© 2011 John Wiley & Sons A/S. |
Affiliation:
|
Department of Medicine and Therapeutics and Institute of Digestive Disease, The Chinese University of Hong Kong; Hong Kong SAR, China Department of Medicine, Section of Gastroenterology, University of Santo Tomas Hospital, Espana Manila, Philippines. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Updated thresholds for alanine aminotransferase do not exclude significant histological disease in c...
Next Document: Liver transplantation with donors over the expected lifespan in the model for end-staged liver disea...