Document Detail

The effect of cadmium on the hematology and on the activity of delta-aminolevulinic acid dehydratase (ALA-D) in blood and hematopoietic tissues of the flounder, Pleuronectes flesus L.
MedLine Citation:
PMID:  318513     Owner:  NLM     Status:  MEDLINE    
Flounders (Pleuronectes flesus) were exposed to sublethal levels of cadmium (5, 50, and 500 micrograms of Cd2+/liter) for periods of 4 and 9 weeks, and the hematological response as well as the effect on the activity of delta-aminolevulinic acid dehydratase (ALA-D) in blood and blood-forming tissues were investigated. Significant reductions of hematocrit, hemoglobin, and red blood cell count were found in the cadmium-exposed fish. This anemic response was apparent even in flounders exposed to the lowest cadmium concentration, approximately corresponding to 1/4000 of the 96-hr LC50 value. The anemia was accompanied by a significant increase of the ALA-D activity in renal tissues. This indicates a compensatory stimulation of the introductory steps of the hemoglobin biosynthesis. However, the formation of hemoglobin does not seem to be accomplished, which might be due to a disturbed iron metabolism. The cadmium exposure also resulted in a significant increase of the number of lymphocytes, indicating an action on the immunological defense of the fish.
M L Johansson-Sjöbeck; A Larsson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental research     Volume:  17     ISSN:  0013-9351     ISO Abbreviation:  Environ. Res.     Publication Date:  1978 Oct 
Date Detail:
Created Date:  1989-10-23     Completed Date:  1989-10-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0147621     Medline TA:  Environ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  191-204     Citation Subset:  IM    
Department of Zoophysiology, University of Göteborg, Sweden.
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MeSH Terms
Blood Cell Count
Cadmium / toxicity*
Erythrocytes / drug effects,  metabolism
Follow-Up Studies
Hematopoietic System / drug effects*,  metabolism
Kidney / drug effects*
Leukocytes / drug effects,  metabolism
Porphobilinogen Synthase / blood*
Spleen / drug effects*
Water Pollutants*
Water Pollutants, Chemical*
Reg. No./Substance:
0/Water Pollutants; 0/Water Pollutants, Chemical; 7440-43-9/Cadmium; EC Synthase

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