Document Detail

The effect of cadmium on antibody responses to antigens with different cellular requirements.
MedLine Citation:
PMID:  3492449     Owner:  NLM     Status:  MEDLINE    
Six week old BDF1 or CD-1 female mice were exposed to cadmium chloride in the drinking water at concentrations ranging from 0 to 50 ppm cadmium for 3 weeks. The in vivo antibody response against dinitrophenyl-aminoethylcarbamylmethyl-Ficoll (DNP-Ficoll), a T-lymphocyte independent, macrophage dependent response, was enhanced by cadmium. Similarly, the in vivo antibody response against Escherichia coli 0127 (LPS), a T-lymphocyte and macrophage independent response, was also enhanced by cadmium. In contrast, the in vitro antibody response against sheep red blood cells (SRBC), a T-lymphocyte and macrophage dependent response, was suppressed in spleen cell cultures that contained cadmium-exposed non-adherent cells (lymphocytes). Cultures containing cadmium-exposed adherent cells (macrophages) were not suppressed by cadmium. These results suggest that the immunosuppressive effects of cadmium as it relates to humoral immunity involve T-lymphocyte function rather than macrophage or B-lymphocyte activity. The enhanced T-lymphocyte independent antibody responses which accompany suppressed T-lymphocyte-dependent responses following cadmium exposure are an indication of compensatory mechanisms that are associated with the immune system.
B R Blakley; R S Tomar
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of immunopharmacology     Volume:  8     ISSN:  0192-0561     ISO Abbreviation:  Int. J. Immunopharmacol.     Publication Date:  1986  
Date Detail:
Created Date:  1987-03-10     Completed Date:  1987-03-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7904799     Medline TA:  Int J Immunopharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1009-15     Citation Subset:  IM    
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MeSH Terms
Antibody Formation / drug effects*
Antigens / immunology
B-Lymphocytes / drug effects,  immunology
Cadmium / toxicity*
Erythrocytes / immunology
Ficoll / analogs & derivatives,  immunology
Lipopolysaccharides / immunology
Macrophages / drug effects,  immunology
T-Lymphocytes / drug effects,  immunology
Reg. No./Substance:
0/Antigens; 0/DNP-Ficoll; 0/Lipopolysaccharides; 25702-74-3/Ficoll; 7440-43-9/Cadmium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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