| The effect of budipine on the central serotoninergic system. | |
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MedLine Citation:
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PMID: 7187046 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Budipine, a new potential antiparkinsonian drug, did not affect or--in higher doses--inhibited the flexor reflex in spinal rats, having no influence on LSD- or fenfluramine-induced flexor-reflex stimulation. It did not affect the body temperature either of the rat kept at a high ambient temperature or of the rabbit in a normothermic surroundings. It weakened fenfluramine hyperthermia in heat-adapted rats, but not in rabbits. Only in high doses budipine weakened tryptamine-induced clonic convulsions of rat forepaws. Budipine partially prevented fenfluramine-induced depletion of whole brain 5-hydroxytryptamine. The above results show that budipine demonstrates some properties of 5-HT uptake inhibitors. |
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Authors:
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E Przegaliński; K Bigajska; A Lewandowska |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Polish journal of pharmacology and pharmacy Volume: 34 ISSN: 0301-0244 ISO Abbreviation: Pol J Pharmacol Pharm Publication Date: 1982 Nov-Dec |
Date Detail:
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Created Date: 1983-12-20 Completed Date: 1983-12-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0366561 Medline TA: Pol J Pharmacol Pharm Country: POLAND |
Other Details:
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Languages: eng Pagination: 309-15 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antiparkinson Agents / pharmacology* Body Temperature / drug effects Brain Chemistry / drug effects* Fenfluramine / pharmacology Hindlimb / physiology Male Piperidines / pharmacology* Rabbits Rats Rats, Inbred Strains Seizures / chemically induced Serotonin / metabolism, physiology* Tryptamines / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antiparkinson Agents; 0/Piperidines; 0/Tryptamines; 458-24-2/Fenfluramine; 50-67-9/Serotonin; 57982-78-2/budipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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