Document Detail


The effect of a brief sprint interval exercise on growth factors and inflammatory mediators.
MedLine Citation:
PMID:  19057403     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Exercise training efficiency depends on the intensity, volume, duration, and frequency of training, as well as on the athlete's ability to tolerate it. Recent efforts to quantify the effects of aerobic exercise training on hormonal response have suggested that exercise leads to simultaneous changes of antagonistic mediators. The effects of anaerobic exercise on these mediators are not known. Therefore, the aim of the present study was to evaluate the effects of a brief sprint interval session on the balance between anabolic (growth hormone [GH]--> insulin-like growth factor [IGF]-I axis) and catabolic hormones (cortisol), and circulating inflammatory cytokines such as interleukin (IL)-6. Twelve healthy elite junior handball players (17-20 years) participated in the study. Exercise consisted of a 4 x 250-m run on a treadmill, at a constant intensity of 80% of the personal maximal speed. Each run was separated by 3 minutes of rest. Blood samples were collected before, immediately after each 250-m run, and 1 hour after the last run. Exercise led to significant increases in GH (0.3 +/- 0.2 to 5.1 +/- 2.2 ngxml, p < 0.05), IGF binding protein (IGFBP)-3 (4191 +/- 2.48 to 4875 +/- 301 ngxml, p < 0.05), IL-6 (1.3 +/- 0.2 to 2.1 +/- 0.3 pgxml, p < 0.002), testosterone, and testosterone/cortisol ratio, and to a significant decrease in IGFBP-1 levels. Levels of IL-6 remained elevated 1 hour after the end of exercise. Exercise had no significant effects on IGF-I and cortisol levels. Changes in the GH-IGF-I axis and testosterone/cortisol ratio after the brief sprint interval exercise suggested exercise-related anabolic adaptations. The increase in IL-6 may indicate its important role in muscle tissue repair after anaerobic exercise. Changes in the anabolic-catabolic hormonal balance and in inflammatory mediators can be used as an objective tool to gauge the training intensity of different types of anaerobic exercises and training periods.
Authors:
Yoav Meckel; Alon Eliakim; Mariana Seraev; Frank Zaldivar; Dan M Cooper; Michael Sagiv; Dan Nemet
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of strength and conditioning research / National Strength & Conditioning Association     Volume:  23     ISSN:  1533-4287     ISO Abbreviation:  J Strength Cond Res     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-06     Completed Date:  2009-05-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9415084     Medline TA:  J Strength Cond Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  225-30     Citation Subset:  IM    
Affiliation:
Zinman College of Physical Education, Wingate Institute, Netanya, Israel.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Analysis of Variance
Anthropometry
Baseball
Blood Chemical Analysis
Cytokines / blood,  metabolism
Energy Metabolism / physiology
Exercise / physiology*
Exercise Test*
Exercise Tolerance / physiology
Growth Hormone / blood,  metabolism
Humans
Hydrocortisone / blood,  metabolism
Inflammation Mediators / blood,  metabolism*
Insulin-Like Growth Factor Binding Proteins / blood,  metabolism
Intercellular Signaling Peptides and Proteins / blood,  metabolism*
Interleukin-6 / blood,  metabolism
Male
Physical Exertion / physiology
Sensitivity and Specificity
Young Adult
Grant Support
ID/Acronym/Agency:
HD 23969/HD/NICHD NIH HHS; MO1-RR00827/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines; 0/Inflammation Mediators; 0/Insulin-Like Growth Factor Binding Proteins; 0/Intercellular Signaling Peptides and Proteins; 0/Interleukin-6; 50-23-7/Hydrocortisone; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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