Document Detail


The effect of brain-derived neurotrophic factor on neuritogenesis and synaptic plasticity in Aplysia neurons and the hippocampal cell line HiB5.
MedLine Citation:
PMID:  12803487     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Brain-derived neurotrophic factor (BDNF) plays a key role in the differentiation and neuritogenesis of developing neurons, and in the synaptic plasticity of mature neurons, in the mammalian nervous system. BDNF binds to the receptor tyrosine kinase TrkB and transmits neurotrophic signals by activating neuron-specific tyrosine phosphorylation pathways. However, the neurotrophic function of BDNF in Aplysia neurons is poorly understood. We examined the specific effect of BDNF on neurite outgrowth and synaptic plasticity in cultured Aplysia neurons and a multipotent rat hippocampal stem cell line (HiB5). Our study indicates that mammalian BDNF has no significant effect on the neuritogenesis, neurotransmitter release, excitability, and synaptic plasticity of cultured Aplysia neurons in our experimental conditions. In contrast, BDNF in combination with platelet-derived growth factor (PDGF) increases the length of the neurites and the number of spine-like structures in cells of HiB5.
Authors:
Seung-Hee Lee; Jin-Hee Han; Jung-Hwan Choi; Eun-Young Huh; Yunhee Kim Kwon; Bong-Kiun Kaang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecules and cells     Volume:  15     ISSN:  1016-8478     ISO Abbreviation:  Mol. Cells     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-06-13     Completed Date:  2003-07-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9610936     Medline TA:  Mol Cells     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  233-9     Citation Subset:  IM    
Affiliation:
National Research Laboratory of Neurobiology, Institute of Molecular Biology and Genetics, School of Biological Sciences, Seoul National University, Seoul 151-742, Korea.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aplysia / drug effects,  metabolism*
Brain-Derived Neurotrophic Factor / pharmacology*
Cell Line
Hippocampus / drug effects,  embryology,  metabolism*
Mammals / genetics,  metabolism
Neurons / drug effects,  metabolism
Synapses / drug effects*
Chemical
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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