Document Detail

The effect of bolus injection on circulation times during cardiac arrest.
MedLine Citation:
PMID:  2331257     Owner:  NLM     Status:  MEDLINE    
Previous investigations have shown that peripheral injection of medication during cardiac arrest leads to prolonged circulation times and low peak drug levels. Current Advanced Cardiac Life Support guidelines suggest that administering a bolus of flush solution after injection of medication may hasten drug delivery, but there is little evidence to support this. The purpose of this study is to investigate the effect of peripheral bolus injection on circulation times during cardiac arrest. Measurements of circulation times were made following injection of indocyanine green dye both with and without a bolus of 20 mL saline flush into a peripheral vein of mongrel dogs. There was no difference in systolic, diastolic, or coronary perfusion pressures during the injections with or without bolus injection. Similarly, there was no difference in end-tidal CO2 or in arterial-venous PO2, PCO2, or pH gradient. The circulation time without bolus injection was 77.7 +/- 42.7 seconds while circulation time with the saline flush was 48.3 +/- 20.9 seconds (P less than .001). Peak dye concentration without saline flush was 3.0 +/- 1.0 mg/L, and peak dye concentration with saline flush was 3.8 +/- 0.9 mg/L (P less than .001). We conclude that a bolus injection of 20 mL of saline enhances dye circulation times and peak levels during cardiac arrest in this animal model. The clinical application of this technique warrants further investigation.
C L Emerman; A C Pinchak; D Hancock; J F Hagen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of emergency medicine     Volume:  8     ISSN:  0735-6757     ISO Abbreviation:  Am J Emerg Med     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-06-04     Completed Date:  1990-06-04     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8309942     Medline TA:  Am J Emerg Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  190-3     Citation Subset:  IM    
Department of Emergency Medicine, Case Western Reserve University, Cleveland, OH.
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MeSH Terms
Blood Circulation Time*
Blood Gas Analysis
Blood Pressure
Disease Models, Animal
Heart Arrest / blood,  drug therapy*,  physiopathology
Indocyanine Green / diagnostic use
Injections, Intravenous*
Tissue Distribution
Reg. No./Substance:
3599-32-4/Indocyanine Green

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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