| The effect of blood storage duration on in-hospital mortality: a randomized controlled pilot feasibility trial. | |
| | |
MedLine Citation:
|
PMID: 22257314 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: Whether the duration of storage of blood has an impact on patient outcomes remains controversial. The objective was to determine feasibility of a comparative effectiveness trial to evaluate duration of storage of blood before transfusion on in-hospital mortality. STUDY DESIGN AND METHODS: A single-center randomized controlled trial was performed at an acute care hospital in Canada between June and December 2010, involving consecutive hospitalized patients needing blood transfusion. Patients (n = 910) were randomly assigned in a 1:2 ratio to receive freshest available versus standard-issue (oldest available) blood. Four feasibility criteria were measured: proportion of eligible patients randomized, contrast in age of blood between treatment groups, real-time data acquisition, and trial impact on blood outdating. In-hospital mortality was also reported. RESULTS: A total of 1075 of 1129 patients (95.2%) were eligible and 910 of 1075 (84.7%) were randomized: 309 received freshest available blood (1157 units), and 601 received standard-age blood (2369 units). Contrast in mean age of the oldest blood transfused between groups was 14.6 days: 12.0 (standard deviation [SD], 6.8) days in the fresh arm and 26.6 (SD, 7.8) days in the standard arm. Weekly recruitment and event reporting were achieved for all patients. The blood outdate rate was 0.10%. In-hospital mortality was 10.5%: 35 deaths (11.3%) in the fresh arm and 61 deaths (10.1%) in the standard arm (odds ratio, 1.13; 95% confidence interval [CI], 0.73, 1.76). CONCLUSION: It is feasible to conduct a large comparative effectiveness trial comparing the effect of freshest available versus standard-issue blood on in-hospital mortality. The wide CI around the estimate for in-hospital mortality supports the need for a large trial. |
| | |
Authors:
|
Nancy M Heddle; Richard J Cook; Donald M Arnold; Mark A Crowther; Theodore E Warkentin; Kathryn E Webert; Jack Hirsh; Rebecca L Barty; Yang Liu; Connie Lester; John W Eikelboom |
Related Documents
:
|
8977484 - Role of blood components in ocular silicone oil emulsification. studies on an in vitro ... 22559504 - Conveyor belt effect in the flow through a tube of a viscous fluid with spinning partic... 22113184 - Strategies to reduce the use of blood products: a european perspective. 19144154 - Luteal blood flow and luteal function. 7221224 - Uterine oxygen uptake in the pregnant pygmy goat. 11300444 - Treatment of no-reflow and impaired flow with the nitric oxide donor nitroprusside foll... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-18 |
Journal Detail:
|
Title: Transfusion Volume: - ISSN: 1537-2995 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-19 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0417360 Medline TA: Transfusion Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2012 American Association of Blood Banks. |
Affiliation:
|
From the Department of Medicine, Faculty of Health Sciences, and the Department of Pathology and Molecular Medicine, Faculty of Health Sciences, McMaster University, and the Research and Development and Medical Office, Canadian Blood Services, Hamilton, Ontario, Canada; the Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada; and the Hamilton Regional Laboratory Medicine Program, Hamilton Health Sciences, Hamilton, Ontario, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Genomic signature of natural and anthropogenic stress in wild populations of the waterflea Daphnia m...
Next Document: Multimodal Characterization of a Linear DNA-Based Nanostructure.