Document Detail

The effect of bisphenol A and chlorinated derivatives of bisphenol A on the level of serum vitellogenin in Japanese medaka (Oryzias latipes).
MedLine Citation:
PMID:  15497839     Owner:  NLM     Status:  MEDLINE    
2,2-bis (4-hydroxyphenyl) propane or Bisphenol A (BPA), has been reported to behave as an endocrine disrupter below acute toxic levels, and is widely present in the water environment. Although BPA is easily chlorinated, very little is reported on the effect of chlorinated BPA to the aquatic organisms. In this study, the estrogenic activities of BPA and its chlorinated derivatives were evaluated by the induction of vitellogenin (VTG) in the serum of mature male Japanese medaka. In addition, the effect of sodium hypochlorite on the decomposition of BPA was tested. The relative potencies of estrogenic activities of chlorinated BPA descended in the order 3,3'-diCIBPA>BPA> or =3-CIBPA>3,3',5-triCIBPA, and no estrogenic activity was observed in 3,3',5,5'-tetraCIBPA. Lowest Observed Effect Concentration (LOEC) and No Observed Effect Concentration (NOEC) for both 3-CIBPA and 3,3'-diCIBPA were 500 microg/L and 200 microg/L, respectively. LOEC for 3,3',5-triCIBPA was >500 microg/L. When BPA was reacted with sodium hypochlorite (24 hours; residual chlorine at 1 ppm), however, complete decomposition of BPA and its chlorinated derivatives was observed. The decrease in BPA and its chlorinated derivatives paralleled the decrease in estrogenic potency evaluated by the induction of vitellogenin (VTG) in the serum of mature male Japanese medaka.
A Tabata; N Watanabe; I Yamamoto; Y Ohnishi; M Itoh; T Kamei; Y Magara; Y Terao
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Water science and technology : a journal of the International Association on Water Pollution Research     Volume:  50     ISSN:  0273-1223     ISO Abbreviation:  Water Sci. Technol.     Publication Date:  2004  
Date Detail:
Created Date:  2004-10-22     Completed Date:  2005-01-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9879497     Medline TA:  Water Sci Technol     Country:  England    
Other Details:
Languages:  eng     Pagination:  125-32     Citation Subset:  IM    
Institute of Environmental Ecology, Metocean Environment Inc, Oigawa-cho, Shida-gun, Shizuoka 421-0212, Japan.
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MeSH Terms
Chlorine / chemistry*
Endocrine System / drug effects
Environmental Exposure
Phenols / chemistry,  toxicity*
Sodium Hypochlorite / analysis,  chemistry
Time Factors
Vitellogenesis / drug effects
Vitellogenins / blood*
Water Pollutants, Chemical / toxicity*
Reg. No./Substance:
0/Phenols; 0/Vitellogenins; 0/Water Pollutants, Chemical; 7681-52-9/Sodium Hypochlorite; 7782-50-5/Chlorine; 80-05-7/bisphenol A

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