| The effect of biliary bile acid concentration and composition on the calcium level in human gallbladder bile. | |
| | |
MedLine Citation:
|
PMID: 8184404 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We analyzed total and ionized calcium concentrations in gallbladder bile of 34 humans in four groups: 8 patients with no gallstone, 11 gallstone patients treated with no gallstone dissolution agents, 8 gallstone patients treated with chenodeoxycholic acid (CDCA) and 7 gallstone patients treated with ursodeoxycholic acid (UDCA). We found that total calcium level ranged from 1.40 to 8.01 mmol/liter, closely related to total bile acid concentration (r = 0.759). However, ionized calcium level was maintained in a narrow range of 0.25 to 1.23 mmol/liter and had no relation to total bile acid concentration. UDCA-rich bile showed relatively high level of ionized calcium. We performed ultrafiltration of bile with cut-off molecular weight 1,000 to investigate the interaction between biliary calcium and bile acid aggregates. The proportion of ultrafiltrated bile acid level to that in original bile in the UDCA group was statistically higher than the other groups. Relatively large percentage of smaller bile acid aggregates in UDCA-rich bile may impair its calcium solubility. |
| | |
Authors:
|
N Tamasawa; M Yoneda; I Makino; K Takebe; K Sone; R Kogawa |
Related Documents
:
|
2754334 - Bile acid sulfotransferase i from rat liver sulfates bile acids and 3-hydroxy steroids:... 12360484 - Bile acid depletion and repletion regulate cholangiocyte growth and secretion by a phos... 20531254 - Molecular genetic and bile acid profiles in two japanese patients with 3beta-hydroxy-de... 8743334 - Clinical pharmacokinetics of therapeutic bile acids. 10712554 - Salicylates of intact salix myrsinifolia plantlets do not undergo rapid metabolic turno... 9017164 - Alterations of tamm-horsfall protein immunoreactivity after partial desialylation and d... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Tohoku journal of experimental medicine Volume: 171 ISSN: 0040-8727 ISO Abbreviation: Tohoku J. Exp. Med. Publication Date: 1993 Dec |
Date Detail:
|
Created Date: 1994-06-14 Completed Date: 1994-06-14 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0417355 Medline TA: Tohoku J Exp Med Country: JAPAN |
Other Details:
|
Languages: eng Pagination: 297-307 Citation Subset: IM |
Affiliation:
|
Third Department of Internal Medicine, Hirosaki University School of Medicine. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Bile
/
metabolism* Bile Acids and Salts / chemistry, metabolism* Calcium / metabolism* Chenodeoxycholic Acid / therapeutic use Cholelithiasis / drug therapy, metabolism Gallbladder / metabolism* Humans Ion-Selective Electrodes Lipids / analysis Ultrafiltration Ursodeoxycholic Acid / therapeutic use |
| Chemical | |
Reg. No./Substance:
|
0/Bile Acids and Salts; 0/Lipids; 128-13-2/Ursodeoxycholic Acid; 474-25-9/Chenodeoxycholic Acid; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The effect of serum on low density lipoprotein metabolism of human monocyte-derived macrophages.
Next Document: Relationship between molecular state of serum HBV-DNA and clinical features of hepatitis B virus car...