Document Detail

The effect of beta-blockers on the diagnostic accuracy of vasodilator pharmacologic SPECT myocardial perfusion imaging.
MedLine Citation:
PMID:  19266249     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The effect of beta (beta) blockers on the accuracy, particularly the sensitivity, of vasodilator radionuclide myocardial perfusion imaging (MPI) is not entirely clear. This study aimed to further assess the effect of beta-blockers on the ability of MPI to identify significant and high-risk coronary artery disease (CAD). METHODS AND RESULTS: For 555 patients who underwent vasodilator MPI and had coronary angiography within 90 days, global and per-vessel sensitivities and specificities were calculated, and were found to be similar between patients taking beta-blockers and those who were not. beta-blockers did not decrease the ability to detect patients with multivessel disease. Summed stress scores and summed rest scores were likewise similar in both groups. To account in part for catheterization referral bias and the potential of false-negative MPI studies in patients receiving beta-blockers, survival analysis was performed on 2646 patients with normal MPI studies who did not undergo cardiac catheterization and failed to demonstrate significant mortality difference related to the taking of beta-blockers. CONCLUSIONS: beta-blocker therapy does not diminish the ability of vasodilator stress MPI to detect clinically significant CAD, nor hide the mortality risk of patients with normal studies not referred for catheterization.
Andrew J Yoon; Rowlens M Melduni; Shelly-Ann Duncan; Robert J Ostfeld; Mark I Travin
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2009-03-06
Journal Detail:
Title:  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology     Volume:  16     ISSN:  1532-6551     ISO Abbreviation:  J Nucl Cardiol     Publication Date:    2009 May-Jun
Date Detail:
Created Date:  2009-05-13     Completed Date:  2009-08-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423534     Medline TA:  J Nucl Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  358-67     Citation Subset:  IM    
Department of Nuclear Medicine and Department of Medicine/Division of Cardiology, Montefiore Medical Center, 111 East-210th Street, Bronx, NY, 10467-2490, USA.
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use*
Coronary Artery Disease / complications,  drug therapy*,  radionuclide imaging*
Drug Interactions
Exercise Test / methods
Middle Aged
Reproducibility of Results
Sensitivity and Specificity
Tomography, Emission-Computed, Single-Photon / methods*
Vasodilator Agents / diagnostic use*
Ventricular Dysfunction, Left / complications,  drug therapy*,  radionuclide imaging*
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Vasodilator Agents

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