Document Detail

The effect of beta blockade on the reaction of pressure and mesenteric flow to biogenic amines in normal and X-irradiated rats.
MedLine Citation:
PMID:  6111139     Owner:  NLM     Status:  MEDLINE    
A beta-blocker, propranolol, was infused to control and irradiated rats the 1st and 3rd day after 2-kR X-ray irradiation. Blood pressure and mesenteric blood flow were recorded during infusion of biogenic amines (noradrenaline, dopamine, serotonin, acetylcholine and histamine). After beta-blockade, there was intensified increase in pressure and decrease in flow with increased overshoot after infusion of noradrenaline, no effect on the increase in pressure and flow after dopamine, but an enhanced increase in pressure and decrease in flow after serotonin. No effect on the decrease in pressure and flow was seen after acetylcholine, and a greater decrease in pressure and flow, after histamine. Irradiation altered the vascular reactivity, mainly for noradrenaline, serotonin and histamine.
R Timmermans; G B Gerber
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Strahlentherapie     Volume:  157     ISSN:  0039-2073     ISO Abbreviation:  Strahlentherapie     Publication Date:  1981 Mar 
Date Detail:
Created Date:  1981-05-28     Completed Date:  1981-05-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1260024     Medline TA:  Strahlentherapie     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  208-12     Citation Subset:  IM    
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MeSH Terms
Acetylcholine / pharmacology
Adrenergic beta-Antagonists / pharmacology*
Blood Pressure / drug effects*
Dopamine / pharmacology
Histamine / pharmacology
Mesenteric Arteries / drug effects*,  radiation effects
Norepinephrine / pharmacology
Propranolol / pharmacology*
Radiation Effects*
Regional Blood Flow / drug effects
Serotonin / pharmacology
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 51-45-6/Histamine; 51-84-3/Acetylcholine; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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