Document Detail


The effect of beta-2 adrenergic receptor haplotype variations on the haemodynamic response following spinal anaesthesia for caesarean delivery.
MedLine Citation:
PMID:  22881137     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated whether genetic variations of the beta-2 adrenergic receptor (ADRB2) modulate the haemodynamic response following spinal anaesthesia for caesarean delivery. We focused on the effects of haplotypes formed by combinations of the Arg16Gly and Gln27Glu polymorphisms. Clinical data from 143 healthy parturients were collected. Only the ArgGln haplotype appeared to influence the risk of hypotension, most probably through a recessive mode of inheritance (p=0.027). Therefore, patients were grouped according to ArgGln homozygosity in two groups: presence of one or no copies of the haplotype (n=120) or two copies of the haplotype (n=23). Both groups presented similar baseline characteristics. Comparatively, patients homozygous for the ArgGln haplotype presented consistently higher blood pressure levels throughout the evaluation period (p=0.001 for systolic arterial pressure variation from baseline). In conclusion, our results demonstrate that haplotype variations of the the ADRB2 modulate the haemodynamic response following spinal anaesthesia for caesarean delivery.
Authors:
M Daher; R B Saito; G B Barra; C S Govêia; E Magalhães; F A R Neves
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-08-13
Journal Detail:
Title:  Anaesthesia     Volume:  67     ISSN:  1365-2044     ISO Abbreviation:  Anaesthesia     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-04     Completed Date:  2012-12-17     Revised Date:  2013-01-24    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  1251-9     Citation Subset:  AIM; IM    
Copyright Information:
Anaesthesia © 2012 The Association of Anaesthetists of Great Britain and Ireland.
Affiliation:
Department of Anaesthesiology, University Hospital of Brasilia, University of Brasilia, Brasilia, Brazil. mdagomes@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Alleles
Anesthesia, Obstetrical*
Anesthesia, Spinal*
Arterial Pressure / physiology
Cesarean Section*
DNA / genetics
Female
Genotype
Haplotypes
Hemodynamics / genetics*,  physiology*
Humans
Hypertension / genetics,  physiopathology
Hypotension / epidemiology,  physiopathology
Kaplan-Meier Estimate
Polymorphism, Genetic
Pregnancy
Receptors, Adrenergic, beta / genetics*
Young Adult
Chemical
Reg. No./Substance:
0/Receptors, Adrenergic, beta; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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