Document Detail

The effect of baked areca nut extract on the growth of buccal mucosa fibroblasts from healthy non-areca nut chewers.
MedLine Citation:
PMID:  9461893     Owner:  NLM     Status:  MEDLINE    
Oral submucous fibrosis is a serious oral disease associated with the habit of chewing areca nut. The habit is relatively common among South Africans of Indian descent. The aim of this study was to observe the effect on growth of buccal mucosa fibroblasts derived from healthy individuals not practising the areca nut habit when the cells are exposed to nut extract. Fibroblast cell-lines from 6 individuals were grown in medium without extract and medium containing 50 and 100 [symbol: see text] g/ml extract of baked nut for 8 days. Cells not exposed to the nut extract behaved homogeneously. Reaction to the nut extracts, however, was dissimilar. The cells of 5 individuals showed no discernable reaction to the extracts while in one instance, the cells of a healthy adult male with no physical disabilities, showed marked growth inhibition. Thus, the finding indicates that when the effect of the nut or its constituents are tested on cells, it is necessary to use several cell-lines of the same cell type or a cell-line of which the growth parameters are standardized.
C W van Wyk; C M de Miranda; A Olivier; P van der Bijl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of the Dental Association of South Africa = Die Tydskrif van die Tandheelkundige Vereniging van Suid-Afrika     Volume:  51     ISSN:  0011-8516     ISO Abbreviation:  J. Dent. Assoc. S. Afr.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1998-03-03     Completed Date:  1998-03-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7505600     Medline TA:  J Dent Assoc S Afr     Country:  SOUTH AFRICA    
Other Details:
Languages:  eng     Pagination:  29-31     Citation Subset:  D    
Oral and Dental Research Institute, Faculty of Dentistry, University of Stellenbosch, Tygerberg.
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MeSH Terms
Areca / chemistry*
Cells, Cultured
Dose-Response Relationship, Drug
Fibroblasts / cytology,  drug effects
Mouth Mucosa / cytology,  drug effects*
Plant Extracts / pharmacology*
Plants, Medicinal*
Reference Values
Time Factors
Reg. No./Substance:
0/Plant Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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