| The effect of augmenting portal venous inflow on intrahepatic pressure and resistance in the isolated perfused porcine liver. | |
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MedLine Citation:
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PMID: 11490787 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: The literature regarding the relationship between portal venous flow and pressure is controversial. The aim of this study was to examine the effects of doubling portal venous inflow on hepatic hemodynamics. METHODOLOGY: Portal venous pressure, intrahepatic portal venous resistance, hepatic arterial pressure and intrahepatic arterial resistance were assessed during basal portal venous inflow (756 +/- 142 mL/min; mean +/- SD) and enhanced portal venous inflow (1512 +/- 284 mL/min) in an isolated perfused normal porcine liver model (n = 6). Hepatic arterial flow was maintained constant throughout the experiments. RESULTS: During the period of enhanced portal venous flow there was an increase in: portal venous pressure (from 9 +/- 2 to 22 +/- 7 mm Hg, P = 0.0076); the difference between portal venous and hepatic venous pressures (from 2 +/- 2 to 10 +/- 5 mm Hg; P = 0.0289); hepatic arterial pressure (from 84 +/- 9 to 151 +/- 33 mm Hg, P = 0.0019); and intrahepatic arterial resistance (from 0.3488 +/- 0.0637 to 0.6387 +/- 0.2020, P = 0.0046). CONCLUSIONS: The increases in hepatic artery pressure and intrahepatic arterial resistance are a result of the hepatic arterial 'buffer response', a phenomenon not previously demonstrated in vitro. The magnitude of the observed changes in portal venous and hepatic venous pressure leads to the conclusion that, in the porcine liver, the intrahepatic venous resistance sites react by constricting to increases in portal venous inflow. |
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Authors:
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L R Jiao; F S Inglott; R T Mathie; N A Habib |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hepato-gastroenterology Volume: 48 ISSN: 0172-6390 ISO Abbreviation: Hepatogastroenterology Publication Date: 2001 Jul-Aug |
Date Detail:
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Created Date: 2001-08-08 Completed Date: 2001-12-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8007849 Medline TA: Hepatogastroenterology Country: Greece |
Other Details:
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Languages: eng Pagination: 1011-4 Citation Subset: IM |
Affiliation:
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Department of Gastrointestinal Surgery, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Hemodynamics Liver / pathology, physiopathology* Perfusion Portal Vein / physiology* Swine Vascular Resistance* |
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