| The effect of aspirin on the ventilatory response to exercise in chronic heart failure. | |
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MedLine Citation:
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PMID: 15542410 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Patients with chronic heart failure (CHF) experience breathlessness and fatigue on exercise. One of the abnormalities seen on maximal exercise testing is an increased ventilatory response to exercise (VE/VCO(2) slope). The cause of this is unknown, but is likely to be due to a combination of interacting peripheral and central factors. Recent data have demonstrated a relation between VE/VCO(2) slope and prostaglandin levels in contracting muscles. The present study examined the influence of the presence of a potent non-selective prostaglandin inhibitor, aspirin, on the ventilatory response to exercise in a group of patients with CHF. METHODS: We investigated the ventilatory response to exercise of 120 consecutive patients in sinus rhythm attending a specialist heart failure clinic. We excluded those taking clopidogrel (six patients) and those on both warfarin and aspirin or taking other non-steroidal anti-inflammatory agents (five patients). The other 109 patients were grouped according to whether they were taking aspirin (n=52 (48%)) or not (n=57 (52%)). Each patient underwent echocardiography to assess left ventricular function, and exercise testing with metabolic gas exchange to derive peak oxygen consumption (pVO(2)) and the VE/VCO(2) slope. RESULTS: The groups were similar in terms of age, (67 (13) vs. 66 (12) years; P=0.34) drug use, heart failure aetiology, left ventricular function (ejection fraction; 33.3 (9.4) vs. 31.8 (9.9)%; P=0.05)) and exercise tolerance (pVO(2); 20.4 (5.3) vs. 19.9 (6.0); P=0.68, and VE/VCO(2) slope; 35.4 (6.2) vs. 35.7 (9.3); P=0.73). There was no difference in the ventilatory response to exercise or the symptoms of breathlessness between the two groups. CONCLUSIONS: Aspirin does not appear to affect exercise performance in CHF. |
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Authors:
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Klaus K A Witte; Andrew L Clark |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of heart failure Volume: 6 ISSN: 1388-9842 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-11-15 Completed Date: 2005-02-22 Revised Date: 2011-06-08 |
Medline Journal Info:
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Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
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Languages: eng Pagination: 745-8 Citation Subset: IM |
Affiliation:
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Department of Academic Cardiology, Castle Hill Hospital, Castle Road, Cottingham Hull, HU16 5JQ, UK. klauswhite@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anti-Inflammatory Agents, Non-Steroidal / pharmacology* Aspirin / pharmacology* Exercise Test Female Heart Failure / physiopathology* Humans Male Middle Aged Oxygen Consumption Respiration / drug effects* Ventricular Function, Left |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 50-78-2/Aspirin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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