Document Detail

The effect of ascorbic acid supplementation on the nicotine metabolism of smokers.
MedLine Citation:
PMID:  10600424     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The relationship of serum ascorbic acid (AA) levels and excretion of nicotine metabolites was determined in 75 men who smoked at least one pack of cigarettes per day. METHODS: The subjects were randomly divided into three groups of 25 each who received a placebo, 200 mg of supplementation, or 1000 mg of supplementation of AA per day for 1 month. Baseline and weekly serum AA levels were determined and simultaneous estimates of urinary excretion of nicotine metabolites as cotinine equivalents (CE). RESULTS: The group mean serum AA levels in the placebo group decreased 13% after 2 weeks; the group mean serum levels of the supplemented groups increased significantly after 1 week (P </= 0. 001) and remained elevated over 100% per week from baseline throughout the study. There was a progressive increase in urinary CE excretion in the placebo group. In the supplemented groups, group mean CE excretion decreased an average of 5% weekly in the 200-mg group and an average of 33% weekly in the 1000-mg group. Pearson's correlation between serum AA and urine CE excretion was significant (r = -0.7980, P </= 0.0003). CONCLUSIONS: Body levels of AA affect the level of urinary nicotine metabolites. The results of this study indicate that dietary levels of AA are inversely correlated to urinary excretion of nicotine metabolites and may be due to suppressed: (1) nicotine intake by smokers who smoked fewer cigarettes or inhale less deeply, (2) nicotine metabolism, or (3) both.
E B Dawson; D R Evans; W A Harris; W J McGanity
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Preventive medicine     Volume:  29     ISSN:  0091-7435     ISO Abbreviation:  Prev Med     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-01-24     Completed Date:  2000-01-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0322116     Medline TA:  Prev Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  451-4     Citation Subset:  IM    
Copyright Information:
Copyright 1999 American Health Foundation and Academic Press.
Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas 77555, USA.
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MeSH Terms
Analysis of Variance
Ascorbic Acid / blood,  pharmacology*
Cotinine / urine
Dose-Response Relationship, Drug
Nicotine / pharmacokinetics,  urine*
Smoking / physiopathology*
Time Factors
Reg. No./Substance:
486-56-6/Cotinine; 50-81-7/Ascorbic Acid; 54-11-5/Nicotine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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