| The effect of arginine supplementation on growth hormone release and intestinal mucosal growth after massive small bowel resection in growing rats. | |
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MedLine Citation:
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PMID: 9269960 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Four-week-old male Sprague-Dawley rats underwent a 90% small bowel resection. From the fourth day after surgery, they were divided into group 1 and 2, and pair-fed by elemental diets (0.8 kcal/mL, 50 mL/day) with L-arginine (n = 10) or L-glycine (n = 11) as an isonitrogenous and isoenergetic supplement for 3 weeks. They were compared with each other 3 weeks after surgery. A statistical analysis was performed using the unpaired Student's t test and the one-way factorial analysis of variance (ANOVA) using Bonferroni/Dunn multiple comparison test. A Pvalue of < .05 was considered significant. There were no significant differences between the two groups in food intake, body weight, tail length, residual ileal length, and plasma IGF-I level. However, the mean height of ileal villi in group 1 showed higher than that in group 2 (P < .01). Growth hormone-releasing hormone (GHRH) provocative tests (1 microg per rat, intravenously) showed the more significant elevation of growth hormone IGH) secretion in the arginine supplement group than that of glycine supplement group at 5 minutes (P < .05). There were no significant differences between basal levels of plasma rat GH in both groups. It is suggested that arginine has a possible significant role of GH secretion and intestinal mucosal growth after massive small bowel resection. |
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Authors:
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T Hebiguchi; T Kato; H Yoshino; M Mizuno; K Koyama |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pediatric surgery Volume: 32 ISSN: 0022-3468 ISO Abbreviation: J. Pediatr. Surg. Publication Date: 1997 Aug |
Date Detail:
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Created Date: 1997-10-06 Completed Date: 1997-10-06 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0052631 Medline TA: J Pediatr Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1149-53 Citation Subset: IM |
Affiliation:
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Department of Pediatric Surgery, Akita University School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Arginine / pharmacology* Food, Fortified* Growth Hormone / secretion* Intestinal Mucosa / drug effects, growth & development* Intestine, Small / surgery* Male Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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74-79-3/Arginine; 9002-72-6/Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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