Document Detail

The effect of aortic valve replacement on quality of life in symptomatic patients with severe aortic stenosis.
MedLine Citation:
PMID:  23239448     Owner:  NLM     Status:  PubMed-not-MEDLINE    
BACKGROUND: Although symptomatic patients with severe aortic stenosis have a high disease burden and guidelines recommend aortic valve replacement, many are treated conservatively. This study describes to what extent quality of life is changed by aortic valve replacement relative to conservative treatment.
METHODS: This observational study followed 132 symptomatic patients with severe aortic stenosis who were subjected to an SF-36v2TM Health Survey.
RESULTS: At baseline 84 patients were treated conservatively, 48 were referred for aortic valve replacement. In the conservatively treated group 15 patients died during a mean follow-up of 18 months (Kaplan-Meier survival was 85 % and 72 % at one and 2 years respectively) and 22 patients crossed over to the surgical group. Of the resulting 70 patients in the surgical group 3 patients died during a mean follow-up of 11 months (survival 95 % at 1 year). Physical functioning, vitality and general health improved significantly 1 year after aortic valve replacement. In conservatively treated patients physical quality of life deteriorated over time while general health, vitality and social functioning showed a declining trend. Mental health remained stable in both groups.
CONCLUSIONS: Aortic valve replacement improves physical quality of life, general health and vitality in patients with symptomatic severe aortic stenosis. Besides having a low life expectancy, conservatively treated patients experience deterioration of physical quality of life. Health surveys such as the SF-36v2TM can be valuable tools in monitoring the burden of disease for an individual patient and offer additional help in treatment decisions.
M W A van Geldorp; H J Heuvelman; A P Kappetein; J J V Busschbach; J J M Takkenberg; A J J C Bogers
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation     Volume:  21     ISSN:  1568-5888     ISO Abbreviation:  Neth Heart J     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-24     Completed Date:  2012-12-25     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  101095458     Medline TA:  Neth Heart J     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  28-35     Citation Subset:  -    
Department of Cardio-thoracic Surgery, Catharina Hospital, PO Box 1350, 5602 ZA, Eindhoven, the Netherlands,
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