Document Detail

The effect of an antimicrobial releasing varnish on root demineralisation in situ. The influence of the demineralisation period.
MedLine Citation:
PMID:  1864854     Owner:  NLM     Status:  MEDLINE    
Caries in exposed root surfaces is becoming a significant problem in dentistry. Varnish applications have interesting preventive possibilities against root caries. The effect of such a varnish, containing two antimicrobials, was studied on the demineralisation of roots with a twofold aim. Firstly, the efficacy of the varnish was investigated in situ as a function of the demineralisation period. Ten participants wore sound intact roots treated with the varnish in an intra oral appliance for 2, 4 and 6 weeks. Secondly, the effect of the varnish on root demineralisation after removal of the varnish was measured. The results showed that the reduction, in demineralization of about 80% after 2 weeks, decreased in magnitude with the length of the in situ demineralisation period. After 4 weeks there was no longer statistically significant difference compared with untreated roots. The acid attack by plaque was, however, substantial in this model; after 6 weeks in situ untreated roots were so strongly demineralised that microradiography was no longer possible anymore. In the second experiment in which the varnish was removed 2 days after application there was a trend toward a reduction of about 30% in root demineralisation after 2 weeks. This was not statistically significant when compared with no application.
E D Huizinga; J Arends
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal de biologie buccale     Volume:  19     ISSN:  0301-3952     ISO Abbreviation:  J Biol Buccale     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-09-11     Completed Date:  1991-09-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0400336     Medline TA:  J Biol Buccale     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  29-33     Citation Subset:  D; IM    
Laboratory for Materia Technica, University of Groningen, The Netherlands.
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MeSH Terms
Chlorhexidine / administration & dosage,  therapeutic use*
Dental Caries / metabolism,  physiopathology*
Dentin / chemistry,  drug effects
Dentin Solubility / drug effects
Middle Aged
Minerals / chemistry
Thymol / administration & dosage,  therapeutic use*
Time Factors
Tooth Root / chemistry,  drug effects*
Reg. No./Substance:
0/Minerals; 55-56-1/Chlorhexidine; 89-83-8/Thymol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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