Document Detail

The effect of antihypertensive drugs on central blood pressure beyond peripheral blood pressure. Part I: (Patho)-physiology, rationale and perspective on pulse pressure amplification.
MedLine Citation:
PMID:  19149617     Owner:  NLM     Status:  MEDLINE    
The blood pressure (BP) waveform varies substantially between the peripheral conduit (brachial) and the central elastic (aorta) arteries mainly do a gradual increase of systolic BP, as the wave propagates distally. This phenomenon is called BP amplification and is principally generated by the presence of arterial stiffness gradient and wave reflections along the arterial bed. More and more clinical studies suggest that central BP may provide additional information regarding cardiovascular risk beyond peripheral BP. Arterial properties and thus pressure amplification, are modulated by age, cardiovascular risk factors, vasoactive substances and drugs. Recent evidence suggests, beyond any doubt, that antihypertensive drugs affect peripheral and central BP differentially and alter pressure amplification. In the present review (Part I) we deal with the mechanisms underlying: (i) the genesis and recording of BP difference between central and peripheral arteries (pressure amplification), (ii) the rational of differential effect of antihypertensive drugs on pressure amplification, (iii) the pathophysiological role of pressure amplification on cardiovascular disease as well as its clinical and research implications.
Athanassios D Protogerou; Theodore G Papaioannou; John P Lekakis; Jacques Blacher; Michel E Safar
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current pharmaceutical design     Volume:  15     ISSN:  1873-4286     ISO Abbreviation:  Curr. Pharm. Des.     Publication Date:  2009  
Date Detail:
Created Date:  2009-01-19     Completed Date:  2009-04-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602487     Medline TA:  Curr Pharm Des     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  267-71     Citation Subset:  IM    
Hypertension Center, 3rd University Dept. of Medicine, Sotiria Hospital, Medical School, National & Kapodistrian University of Athens, Greece.
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MeSH Terms
Antihypertensive Agents / pharmacology*
Aorta / physiopathology
Blood Pressure / drug effects*
Brachial Artery / physiopathology
Cardiovascular Diseases / etiology,  physiopathology
Clinical Trials as Topic
Hypertension / drug therapy*,  physiopathology
Risk Factors
Reg. No./Substance:
0/Antihypertensive Agents

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