| The effect of antihypertensive drugs on central blood pressure beyond peripheral blood pressure. Part I: (Patho)-physiology, rationale and perspective on pulse pressure amplification. | |
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MedLine Citation:
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PMID: 19149617 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The blood pressure (BP) waveform varies substantially between the peripheral conduit (brachial) and the central elastic (aorta) arteries mainly do a gradual increase of systolic BP, as the wave propagates distally. This phenomenon is called BP amplification and is principally generated by the presence of arterial stiffness gradient and wave reflections along the arterial bed. More and more clinical studies suggest that central BP may provide additional information regarding cardiovascular risk beyond peripheral BP. Arterial properties and thus pressure amplification, are modulated by age, cardiovascular risk factors, vasoactive substances and drugs. Recent evidence suggests, beyond any doubt, that antihypertensive drugs affect peripheral and central BP differentially and alter pressure amplification. In the present review (Part I) we deal with the mechanisms underlying: (i) the genesis and recording of BP difference between central and peripheral arteries (pressure amplification), (ii) the rational of differential effect of antihypertensive drugs on pressure amplification, (iii) the pathophysiological role of pressure amplification on cardiovascular disease as well as its clinical and research implications. |
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Authors:
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Athanassios D Protogerou; Theodore G Papaioannou; John P Lekakis; Jacques Blacher; Michel E Safar |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current pharmaceutical design Volume: 15 ISSN: 1873-4286 ISO Abbreviation: Curr. Pharm. Des. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-01-19 Completed Date: 2009-04-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9602487 Medline TA: Curr Pharm Des Country: Netherlands |
Other Details:
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Languages: eng Pagination: 267-71 Citation Subset: IM |
Affiliation:
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Hypertension Center, 3rd University Dept. of Medicine, Sotiria Hospital, Medical School, National & Kapodistrian University of Athens, Greece. aprotog@med.uoa.gr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antihypertensive Agents
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pharmacology* Aorta / physiopathology Blood Pressure / drug effects* Brachial Artery / physiopathology Cardiovascular Diseases / etiology, physiopathology Clinical Trials as Topic Humans Hypertension / drug therapy*, physiopathology Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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