Document Detail

The effect of antifungal agents on the in vitro susceptibility of Candida albicans to apo-lactoferrin.
MedLine Citation:
PMID:  7741664     Owner:  NLM     Status:  MEDLINE    
The effect of subminimal inhibitory concentrations (MICs) of nystatin, amphotericin B, clotrimazole, miconazole and 5-fluorocytosine on the in vitro susceptibility of Candida albicans to physiological concentrations of apo-lactoferrin was investigated. Pre-exposure of C. albicans in 1:4 and 1:16 MICs of the antifungals resulted in an increased resistance to apo-lactoferrin-mediated cell death. Preincubation of Candida in tunicamycin (an agent that inhibits the synthesis of yeast cell-wall mannoproteins) and subsequent exposure to apo-lactoferrin enhanced the antifungal activity, whilst addition of ergosterol (a yeast cell-wall component) to the assay suspension had no significant effect. These results taken together indicate that apo-lactoferrin, an important component of saliva, interacts with cell-membrane constituents of C. albicans such as mannoproteins, and may modulate the effect of topical antifungal agents commonly prescribed for oral candidoses.
H Nikawa; L P Samaranayake; J Tenovuo; T Hamada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of oral biology     Volume:  39     ISSN:  0003-9969     ISO Abbreviation:  Arch. Oral Biol.     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1995-06-08     Completed Date:  1995-06-08     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0116711     Medline TA:  Arch Oral Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  921-3     Citation Subset:  D; IM    
Oral Biology Unit, Prince Phillip Dental Hospital, University of Hong Kong.
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MeSH Terms
Amphotericin B / pharmacology
Antifungal Agents / pharmacology*
Apoproteins / pharmacology*
Candida albicans / drug effects*
Cell Death / drug effects
Cell Wall / chemistry
Clotrimazole / pharmacology
Drug Resistance, Microbial
Ergosterol / pharmacology
Flucytosine / pharmacology
Lactoferrin / pharmacology*
Membrane Glycoproteins / antagonists & inhibitors
Miconazole / pharmacology
Nystatin / pharmacology
Tunicamycin / pharmacology
Reg. No./Substance:
0/Antifungal Agents; 0/Apoproteins; 0/Lactoferrin; 0/Membrane Glycoproteins; 0/apolactoferrin; 0/mannoproteins; 11089-65-9/Tunicamycin; 1397-89-3/Amphotericin B; 1400-61-9/Nystatin; 2022-85-7/Flucytosine; 22916-47-8/Miconazole; 23593-75-1/Clotrimazole; 57-87-4/Ergosterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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