| The effect of anticoagulation on antenatal ultrasound findings in pregnant women with thrombophilia. | |
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MedLine Citation:
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PMID: 16492587 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess whether treatment with heparin alters ultrasound findings in pregnant women with inherited thrombophilia. METHODS: This was a retrospective study of a cohort of patients referred for pregnancy complications who were found to have genetic thrombophilia. Ultrasounds were reviewed in treated and untreated pregnancies for the presence of growth restriction, oligohydramnios or abnormal Doppler results. RESULTS: There were a total of 178 pregnancies in 51 patients. The overall percentage of abnormal ultrasounds was significantly greater in the untreated compared with treated pregnancies (52.8% vs. 27.9%; p = 0.024.) Growth restriction and abnormal Doppler results were more common in untreated pregnancies. There was a significantly decreased risk of oligohydramnios with treatment (27.3% vs. 7%; p = 0.03). Overall outcomes were significantly improved with the use of anticoagulation ( p < 0.0001). CONCLUSIONS: Treatment markedly improves ultrasound parameters of growth, fluid and feto-placental blood flow in patients with thrombophilia. The presence of abnormalities despite treatment reinforces the need for close antenatal surveillance. |
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Authors:
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Urania Magriples; Tulin Ozcan; Anita Karne; Joshua Abbott Copel |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: 19 ISSN: 1476-7058 ISO Abbreviation: J. Matern. Fetal. Neonatal. Med. Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2006-02-22 Completed Date: 2006-08-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: United States |
Other Details:
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Languages: eng Pagination: 27-30 Citation Subset: IM |
Affiliation:
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Department of Obstetrics & Gynecology, Yale University School of Medicine, New Haven, Connecticut 06504, USA. urania.magriples@yale.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anticoagulants / therapeutic use* Cohort Studies Female Fetal Death / ultrasonography Fetal Growth Retardation / prevention & control, ultrasonography Heparin / therapeutic use* Humans Mutation Oligohydramnios / prevention & control, ultrasonography Pregnancy Pregnancy Complications, Hematologic / diagnosis, drug therapy*, genetics Pregnancy Outcome Retrospective Studies Thrombophilia / diagnosis, drug therapy*, genetics Ultrasonography, Doppler Ultrasonography, Prenatal* |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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