Document Detail

The effect of antibiotics on bacteria under hyperbaric conditions.
MedLine Citation:
PMID:  8707735     Owner:  NLM     Status:  MEDLINE    
The sensitivity of selected bacteria to a range of antibiotics was tested under hyperbaric conditions used in saturation diving. The effect of hyperbaric helium and oxygen (heliox) on antibiotic stability and on induction of beta-lactamase was also determined. Increased resistance to penicillin (up to 23%) was shown by Staphylococcus aureus and to gentamicin (up to 46%) and rifampicin (up to 18%) by Escherichia coli and Salmonella typhimurium at 36 and 71 bar pressure. Exposure to 71 bar heliox did not affect antibiotic activity but increased the production of beta-lactamase in inducible S. aureus and Bacillus subtilis and production of beta-galactosidase in inducible E. coli. Increased resistance to antibiotics in saturation diving conditions can be attributed in some cases to the influence of hyperbaric pressure on induction mechanisms in bacteria. The experimental system devised for this work is suitable for more detailed examination of the influence of hyperbaric stress on antibiotic resistance and of its effect on induction mechanisms in general.
J Hind; R W Attwell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of antimicrobial chemotherapy     Volume:  37     ISSN:  0305-7453     ISO Abbreviation:  J. Antimicrob. Chemother.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-09-06     Completed Date:  1996-09-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7513617     Medline TA:  J Antimicrob Chemother     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  253-63     Citation Subset:  IM    
University of Maryland, Center of Marine Biotechnology, Baltimore 21202, USA.
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MeSH Terms
Anti-Bacterial Agents / pharmacology*
Diving* / adverse effects
Drug Resistance, Microbial
Helium / pharmacology*
Hyperbaric Oxygenation*
Microbial Sensitivity Tests*
beta-Lactamases / biosynthesis
Reg. No./Substance:
0/Anti-Bacterial Agents; 7440-59-7/Helium; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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