| The effect of antiandrogens and stilboestrol on the cytosol receptor in rat prostate. | |
| | |
MedLine Citation:
|
PMID: 74269 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effects of 4 antiandrogens and stilboestrol on the cytosol receptor of the rat ventral prostate have been compared. Equimolar doses of cyproterone acetate, chlormadinone acetate, SC 9022 and flutamide inhibited the binding of dihydrotestosterone to the receptor complex in vivo by 44 to 50% whereas stilboestrol had no effect. In the in vitro studies an equimolar concentration produced similar effects to those observed in vivo with the exception of flutamide which had no effect. This technique provides a method for assessing and comparing the effectiveness of antiandrogens on the androgen receptor complex of the prostate. |
| | |
Authors:
|
R Ghanadian; C B Smith; G Williams; G D Chisholm |
Related Documents
:
|
3350289 - Increased hepatic androgen receptor expression in female rats during diethylnitrosamine... 10334909 - Phosphorylation/dephosphorylation of androgen receptor as a determinant of androgen ago... 18406259 - The androgen receptor as mediator of gene expression and signal transduction pathways. 15757859 - Androgen receptor gene cag and ggc repeat lengths in cryptorchidism. 15308689 - Coregulator recruitment and histone modifications in transcriptional regulation by the ... 14517289 - The cochaperone bag-1l enhances androgen receptor action via interaction with the nh2-t... 12373529 - Glutamatergic mechanisms in different disease states: overview and therapeutical implic... 12775329 - Involvement of 5-ht1a receptors in animal tests of anxiety and depression: evidence fro... 17207629 - Reduced gabab receptor subunit expression and paired-pulse depression in a genetic mode... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: British journal of urology Volume: 49 ISSN: 0007-1331 ISO Abbreviation: Br J Urol Publication Date: 1977 |
Date Detail:
|
Created Date: 1978-03-21 Completed Date: 1978-03-21 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 15740090R Medline TA: Br J Urol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 695-700 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Androgen Antagonists
/
pharmacology* Animals Chlormadinone Acetate / pharmacology Cyproterone / pharmacology Cytosol / drug effects, metabolism* Diethylstilbestrol / pharmacology* Dihydrotestosterone / metabolism Flutamide / pharmacology Male Nandrolone / analogs & derivatives, pharmacology Prostate / drug effects, metabolism* Rats Receptors, Androgen / drug effects*, metabolism Receptors, Steroid / drug effects* |
| Chemical | |
Reg. No./Substance:
|
0/Androgen Antagonists; 0/Receptors, Androgen; 0/Receptors, Steroid; 13311-84-7/Flutamide; 2098-66-0/Cyproterone; 302-22-7/Chlormadinone Acetate; 434-22-0/Nandrolone; 521-18-6/Dihydrotestosterone; 56-53-1/Diethylstilbestrol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Guanethidine-induced vasodilatation in the rabbit, mediated by endogenous histamine.
Next Document: Carcinoma of the penis: a review of 42 cases.