Document Detail

The effect of anti-hypertensive therapy on urinary albumin excretion in Nigerian hypertensives.
MedLine Citation:
PMID:  10593151     Owner:  NLM     Status:  MEDLINE    
The effect of blood pressure control on urinary protein excretion was assessed in 24 benign essential hypertensive subjects (12 males and 12 females). There were 23 controls (11 males and 12 females). Mean ages were 55 and 53 years respectively. Twenty-four hours urine was collected from each subject before and after control of blood pressure, while the controls had only one 24 h urine sample collected. 24 h urinary albumin excretion was assessed using the Bromocresol Green Method. Control of blood pressure in the subjects took an average of eight weeks. Subjects were either given hydroflumethiazide, alpha-methyldopa and/or prazosin as required. Blood pressure was measured in the right arm at each visit and pill counting was used to assess the compliance with therapy. The average urinary albumin excretion was significantly higher in the hypertensive subjects than the normotensive controls (P < 0.05). The average urinary albumin excretion after control of blood pressure was also significantly lower than, before control of blood pressure (P < 0.02). There was no correlation between SBP, DBP, MAP, and 24 h urinary albumin excretion in both subjects and controls. This study has shown that control of blood pressure can reduce or reverse urinary albumin excretion in Nigerian hypertensives.
B L Salako; S Kadiri; F A Fehintola; O O Akinkugbe
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  West African journal of medicine     Volume:  18     ISSN:  0189-160X     ISO Abbreviation:  West Afr J Med     Publication Date:    1999 Jul-Sep
Date Detail:
Created Date:  2000-01-03     Completed Date:  2000-01-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8301891     Medline TA:  West Afr J Med     Country:  NIGERIA    
Other Details:
Languages:  eng     Pagination:  170-4     Citation Subset:  IM    
Department of Medicine, University of College Hospital, Ibadan, Oyo State, Nigeria.
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MeSH Terms
Albuminuria / diagnosis,  etiology*,  urine*
Antihypertensive Agents / pharmacology,  therapeutic use*
Blood Pressure / drug effects
Bromcresol Green / diagnostic use
Case-Control Studies
Creatinine / urine
Hydroflumethiazide / pharmacology,  therapeutic use
Hypertension / complications*,  drug therapy*
Indicators and Reagents
Methyldopa / pharmacology,  therapeutic use
Middle Aged
Prazosin / pharmacology,  therapeutic use
Reg. No./Substance:
0/Antihypertensive Agents; 0/Indicators and Reagents; 135-09-1/Hydroflumethiazide; 19216-56-9/Prazosin; 555-30-6/Methyldopa; 60-27-5/Creatinine; 76-60-8/Bromcresol Green

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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