| The effect of antenatal steroid treatment on fetal autonomic heart rate regulation revealed by fetal magnetocardiography (fMCG). | |
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MedLine Citation:
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PMID: 20547444 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Steroid administration to accelerate fetal lung maturation reduces neonatal morbidity and mortality in the case of preterm delivery. Behavioral observations suggest effects on fetal cardiovascular regulation. AIM: We hypothesize that beat to beat heart rate variability (fHRV) derived from fetal magnetocardiography (fMCG) will reveal a direct, acute steroidal effect on fetal autonomic heart rate regulation. SUBJECTS: Eight patients between 29 and 34 weeks of gestation at risk for preterm birth who were treated with betamethasone (2x12 mg within 24 h). STUDY DESIGN: Subjects were studied prior to the first and within 6 h after the second administration. Continuous fMCG was recorded with a 31-channel-SQUID biomagnetometer. Each dataset was processed by subtracting maternal cardiac artefacts and determining the time instants of the fetal heart beats. fHRV analysis was applied to periods of fetal quiescence of 4 min length. OUTCOME MEASURES: We compared fHRV prior versus post steroid administration. RESULTS: Steroid exposure reduced all parameters of overall fHRV significantly. The fHRV parameters representing short term variability remained unaffected. Mean fetal heart rate significantly decreased. The complexity of the heart rate patterns increased. CONCLUSION: Our results suggest an acute shift in the sympatho-vagal balance of fetuses exposed to betamethasone in utero toward sympathetic suppression. |
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Authors:
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Uwe Schneider; Anja Fiedler; Beatrix Schröder; Susann Jaekel; Angelika Stacke; Dirk Hoyer; Ekkehard Schleussner |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-14 |
Journal Detail:
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Title: Early human development Volume: 86 ISSN: 1872-6232 ISO Abbreviation: Early Hum. Dev. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2010-09-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7708381 Medline TA: Early Hum Dev Country: Ireland |
Other Details:
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Languages: eng Pagination: 319-25 Citation Subset: IM |
Copyright Information:
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2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Obstetrics, Bachstrasse 18, University Hospital, Jena Germany. Uwe.Schneider@med.uni-jena.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Autonomic Pathways / drug effects Betamethasone / adverse effects, pharmacology, therapeutic use Female Fetal Organ Maturity / drug effects Heart Rate, Fetal / drug effects* Humans Magnetocardiography* Pregnancy Prenatal Diagnosis / methods Prenatal Exposure Delayed Effects / chemically induced, diagnosis*, physiopathology Steroids / adverse effects, pharmacology*, therapeutic use Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Steroids; 378-44-9/Betamethasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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