Document Detail

The effect of antenatal phenobarbital therapy on neonatal intracranial hemorrhage in preterm infants.
MedLine Citation:
PMID:  9250849     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The administration of phenobarbital to pregnant women before delivery has been thought to decrease the frequency of intracranial hemorrhage in preterm infants. To evaluate this potential neuroprotective therapy further, we determined the effect of antenatal administration of phenobarbital on the frequency of neonatal intracranial hemorrhage and early death. METHODS: We studied 610 women who were 24 to 33 weeks pregnant and who were expected to deliver their infants within 24 hours. The women were randomly assigned to receive either phenobarbital (10 mg per kilogram of body weight) or placebo intravenously, followed by maintenance doses until delivery or 34 weeks of gestation. The infants born to these women underwent cranial ultrasonography to detect the presence of intracranial hemorrhage. RESULTS: There were 309 women in the phenobarbital group and 301 in the placebo group. A total of 247 women (80 percent) in the phenobarbital group and 235 (78 percent) in the placebo group delivered within 24 hours after infusion of the study drug or administration of the last maintenance dose. Intracranial hemorrhage or early death occurred in 83 of the 344 infants born to the women in the phenobarbital group (24 percent) and in 74 of the 324 born to the women in the placebo group (23 percent; risk ratio for the infants in the phenobarbital group, 1.1; 95 percent confidence interval, 0.8 to 1.4). Among infants born before 34 weeks' gestation in whom ultrasonographic studies were performed, intracranial hemorrhage was diagnosed in 70 of 311 infants in the phenobarbital group (23 percent) and 64 of 279 in the placebo group (23 percent; risk ratio, 1.0; 95 percent confidence interval, 0.8 to 1.4). CONCLUSIONS: Antenatal administration of phenobarbital does not decrease the risk of intracranial hemorrhage or early death in preterm infants.
S Shankaran; L A Papile; L L Wright; R A Ehrenkranz; L Mele; J A Lemons; S B Korones; D K Stevenson; E F Donovan; B J Stoll; A A Fanaroff; W Oh
Related Documents :
3875699 - Intraventricular hemorrhage in a term neonate secondary to a third ventricular avm. cas...
6680649 - Calcified neonatal adrenal hemorrhage: diagnostic and therapeutic considerations.
11949019 - Intraventricular hemorrhage in the term infant.
12671109 - Phase 1 trial of prevention of hydrocephalus after intraventricular hemorrhage in newbo...
2265019 - A study of periventricular haemorrhage, post-haemorrhagic ventricular dilatation and pe...
6518059 - Perinatal factors that influence the incidence of subependymal and intraventricular hem...
12020019 - Behavioral responses and mortality in german cockroaches (blattodea: blattellidae) afte...
3379279 - Infarction of the upper limbs associated with oligohydramnios and intrauterine compress...
17991109 - Fetal growth restriction and other factors associated with neonatal death in new zealand.
Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The New England journal of medicine     Volume:  337     ISSN:  0028-4793     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-08-14     Completed Date:  1997-08-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  466-71     Citation Subset:  AIM; IM    
Wayne State University, Detroit, MI, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cerebral Hemorrhage / prevention & control*,  ultrasonography
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / mortality,  prevention & control*,  ultrasonography
Odds Ratio
Phenobarbital / administration & dosage,  therapeutic use*
Prenatal Care
Treatment Outcome
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Clonality in nodular lymphocyte-predominant Hodgkin's disease.
Next Document:  Sucrose consumption in mice: major influence of two genetic loci affecting peripheral sensory respon...