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The effect of antenatal corticosteroid treatment on the fetal lung-a magnetic resonance imaging study.
MedLine Citation:
PMID:  21308834     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To investigate the effect of antenatal corticosteroid treatment on the fetal lung using magnetic resonance imaging. METHODS: Prospective evaluation of 30 consecutive singleton pregnancies that received antenatal corticosteroid treatment (12 mg Betamethasone i.m. on admission and 24h later) because of threatened preterm birth. Fetal lungs were assessed using T2-weighted single-shot fast spin-echo images of a whole-body 1.5 Tesla superconducting unit twice: less than 24h and more than 48h after the first course of Betamethasone. Lung volumes and lung-liver signal intensity ratios were compared between the two time points. RESULTS: 9 patients had to be excluded from the analysis because they did not complete the study protocol as required. 10 female and 11 male fetuses with a gestational age between 23.4 and 32.6 weeks were included in the final analysis. The mean gestational age of included fetuses was 27.5 ± 2.8 weeks. Using a linear regression model a significant influence of gestational age on ln fetal lung volume (r(2) = 0.414; p<0.0001) and lung-liver signal intensity ratios (r(2) = 0.271, p<0.0001) was found. Between the two evaluated time points a significant increase in lung-liver signal intensity ratios (2.34 ± 0.72 vs. 3.22 ± 1.12, p< 0.0001) but not in mean lung volumes (46.6 ± 20.7cm(3) vs. 48.8 ± 16.0cm(3) , p = 0.292) was observed. CONCLUSION: We demonstrate a significant increase in lung-liver signal intensity ratios after antenatal corticosteroid treatment for induction of lung maturation which most likely reflects changing properties of the fetal lung parenchyma. This could potentially be useful in non-invasively assessing the effect of antenatal corticosteroid treatment on fetuses at risk for preterm birth. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd.
Maximilian Schmid; Gregor Kasprian; Lorenz Kuessel; Agnes Messerschmidt; Peter C Brugger; Daniela Prayer
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-24
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  -     ISSN:  1469-0705     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-2-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd.
Department of Obstetrics and Feto-maternal Medicine, Medical University of Vienna, Austria.
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