| The effect of angiotensin-converting enzyme inhibition by captopril on respiratory mechanics in healthy rats. | |
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MedLine Citation:
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PMID: 22591316 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Context: Angiotensin stimulates smooth-muscle contraction. Accordingly, angiotensin-converting enzyme (ACE) inhibition is expected to decrease airway resistance. Objectives: To measure the effects of ACE inhibition on respiratory mechanics in healthy mammals. Materials and methods: We measured respiratory mechanics before and after i.p. ACE inhibitor captopril (100 mg/kg) in normal anaesthetised rats. The end-inflation occlusion method allowed the measurements of respiratory system elastance and ohmic and viscoelastic pressure dissipations. Respiratory system hysteresis and the elastic and resistive work of breathing were calculated. Results: Captopril induced a reduction of the ohmic and the total respiratory system resistances, while respiratory system hysteresis and elastance did not change. Accordingly, a reduction of the resistive and of the total work of breathing was observed. Conclusions: The captopril-induced reduction of airway resistance indicates that angiotensin modulates bronchomotor tone in basal conditions. ACE inhibition may positively affect respiratory system mechanics and work of breathing. |
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Authors:
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Alessandro Rubini; Marco Redaelli; Andrea Parmagnani |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-16 |
Journal Detail:
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Title: Journal of enzyme inhibition and medicinal chemistry Volume: - ISSN: 1475-6374 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101150203 Medline TA: J Enzyme Inhib Med Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Human Anatomy and Physiology, Section Physiology, University of Padova, Via Marzolo , Padova , Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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