| The effect of angiotensin-blocking agents on liver fibrosis in patients with hepatitis C. | |
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MedLine Citation:
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PMID: 19220742 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Multiple studies implicate the renin-angiotensin system in hepatic fibrogenesis. Few studies have examined the effects of angiotensin blockade on liver fibrosis via human histology. AIMS: We studied the histological effect of angiotensin II blocking agents in chronic hepatitis C patients. METHODS: This was a retrospective study of 284 chronic hepatitis C patients from 2001 to 2006 who underwent a liver biopsy. Group I was comprised of 143 hypertensive patients who received angiotensin-blocking agents. Group II was comprised of 91 hypertensive subjects who received hypertensive agents other than angiotensin blockers. Group III was comprised of 50 non-hypertensive subjects. RESULTS: The groups were similar in age, sex, hepatitis C genotype, viral load and disease duration. They varied significantly in total diabetic patients (Group I, 43; Group II, 10; Group III, 1; P=0.0001), consistent with recommended use of angiotensin-converting enzyme inhibitors in hypertensive diabetics. Non-hypertensive patients had significantly less fibrosis than hypertensive patients, regardless of antihypertensive medications (Group I, 3.20; Group II, 3.73; Group III, 2.5; P=0.0002). Group I had significantly less fibrosis than Group II (P=0.02). This finding persisted in a non-diabetic subgroup of Groups I and II (Group I, 3.07; Group II, 3.69; P=0.0129). CONCLUSION: Patients with hepatitis C and hypertension have increased fibrosis compared with non-hypertensive patients. Hypertensive patients receiving angiotensin-blocking agents had less fibrosis than hypertensive patients who did not receive angiotensin-blocking agents. This suggests an association with hypertension, possibly via the renin-angiotensin system in the fibrosis development and suggests a beneficial role of angiotensin II blockade in hepatitis C virus-related fibrosis. |
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Authors:
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Kathleen E Corey; Nirali Shah; Joseph Misdraji; Barham K Abu Dayyeh; Hui Zheng; Atul K Bhan; Raymond T Chung |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2009-02-09 |
Journal Detail:
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Title: Liver international : official journal of the International Association for the Study of the Liver Volume: 29 ISSN: 1478-3231 ISO Abbreviation: Liver Int. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-05-05 Completed Date: 2009-08-10 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 101160857 Medline TA: Liver Int Country: England |
Other Details:
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Languages: eng Pagination: 748-53 Citation Subset: IM |
Affiliation:
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Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Angiotensin-Converting Enzyme Inhibitors / therapeutic use* Female Hepatitis C / complications* Humans Hypertension / drug therapy* Liver Cirrhosis / drug therapy*, etiology Male Massachusetts Middle Aged Retrospective Studies |
| Grant Support | |
ID/Acronym/Agency:
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AI069939-01/AI/NIAID NIH HHS; DK078722/DK/NIDDK NIH HHS; K24 DK078772-01/DK/NIDDK NIH HHS; R01 AI069939-03/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors |
| Comments/Corrections | |
Comment In:
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Liver Int. 2009 Nov;29(10):1597; author reply 1598
[PMID:
19744164
]
Liver Int. 2010 Feb;30(2):334-5 [PMID: 19515217 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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