Document Detail

The effect of angiotensin II on the number of macula densa cells through the AT1 receptor.
MedLine Citation:
PMID:  19407469     Owner:  NLM     Status:  MEDLINE    
The present study was performed to obtain information about a possible correlation between the activity of the renin-angiotensin system and the stereological features of the macula densa (MD). In normal kidneys, the numbers of angiotensin II AT1 receptors were estimated in MD cells and in the neighboring tubular cells. The total volumes of MD, MD cells, neighboring tubular cells, and the total number of MD cells, were measured in normal and candesartan-treated rats (15 mg/kg/day over 21 days). In the normal kidneys, the relative number of AT1 receptors in MD cells [mean = 0.17 (CV = 0.23)] was significantly (p = 0.03) lower than that in normal tubular cells [0.25 (0.21)]. A significant difference (p < 0.01) was observed in the total volume between MD cells [515 microm(3) (0.14)] and normal tubular cells [984 microm(3) (0.19)]. Candesartan treatment significantly elevated (p < 0.01) the total volume of the MD, whereas the total number of MD cells was increased [from 14.2 (0.11) to 19.5 (0.11)]. The results demonstrated that the transdifferentiation from normal tubular cells to MD cells can be controlled by pharmacological means. The structural features of MD controlled by the renin-angiotensin system may be one of the important factors governing the sensitivity of tubuloglomerular feedback.
Zsolt Razga; Jens Randel Nyengaard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-04-29
Journal Detail:
Title:  Nephron. Physiology     Volume:  112     ISSN:  1660-2137     ISO Abbreviation:  Nephron Physiol     Publication Date:  2009  
Date Detail:
Created Date:  2009-05-29     Completed Date:  2009-07-23     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  101159772     Medline TA:  Nephron Physiol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  p37-43     Citation Subset:  IM    
Department of Pathology, University of Szeged, Szeged, Hungary.
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MeSH Terms
Angiotensin II / metabolism*
Angiotensin II Type 1 Receptor Blockers / pharmacology
Benzimidazoles / pharmacology
Cell Count
Cell Proliferation / drug effects
Cell Transdifferentiation* / drug effects
Epithelial Cells / drug effects,  metabolism*
Juxtaglomerular Apparatus / cytology,  drug effects,  metabolism*
Rats, Wistar
Receptor, Angiotensin, Type 1 / drug effects,  metabolism*
Tetrazoles / pharmacology
Reg. No./Substance:
0/Angiotensin II Type 1 Receptor Blockers; 0/Benzimidazoles; 0/Receptor, Angiotensin, Type 1; 0/Tetrazoles; 11128-99-7/Angiotensin II; S8Q36MD2XX/candesartan

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